Pruthi A K, Gupta R K, Sadana J R
Res Vet Sci. 1987 Mar;42(2):145-9.
A bivalent vaccine was prepared by combining inactivated Marek's disease virus and turkey herpesvirus. The efficacy of this vaccine, compared to turkey herpesvirus and inactivated Marek's disease virus separately, was studied in unsexed White Leghorn chicks which were vaccinated at one day old and then challenged at 21 days old with fowl blood infected with virulent Marek's disease virus. The bivalent vaccine appreciably delayed mortality resulting from Marek's disease and elicited the highest protective efficacy as judged on the basis of Marek's disease-specific mortality and percentage occurrence of lesions. The occurrence, extent and severity of gross lymphomas and microscopic lymphoproliferative lesions in various organs of the bivalent vaccinated birds were less than in the other challenged groups. In addition, the level of viraemia remained consistently and significantly lower in the bivalent vaccinated birds.
一种二价疫苗是通过将灭活的马立克氏病病毒和火鸡疱疹病毒组合而成的。在一日龄时接种疫苗，然后在21日龄时用感染了强毒马立克氏病病毒的禽血进行攻毒的未分性别的白来航雏鸡中，研究了这种疫苗与单独使用火鸡疱疹病毒和灭活马立克氏病病毒相比的效力。根据马立克氏病特异性死亡率和病变发生率判断，二价疫苗明显延迟了马立克氏病导致的死亡，并引发了最高的保护效力。二价疫苗接种的鸡的各个器官中大体淋巴瘤和微观淋巴增生性病变的发生、范围和严重程度均低于其他攻毒组。此外，二价疫苗接种的鸡的病毒血症水平一直显著较低。
