Welch P A, Namen A E, Goodwin R G, Armitage R, Cooper M D
Division of Developmental and Clinical Immunology, University of Alabama, Birmingham 35294.
J Immunol. 1989 Dec 1;143(11):3562-7.
IL-7 is a hemopoietic growth factor that induces the proliferation of early B lineage cells. In the course of studies to determine its effect on human bone marrow cells, we noted a marked outgrowth of mature T cells. When T cells from the circulation were cultured with IL-7, a dose-dependent proliferative response was observed. The target cells included both the CD4+ and CD8+ subpopulations of T cells, but the memory T cells (CD45R-) were better responders than unprimed T cells (CD45R+). IL-7 induced the expression of receptors for IL-2 and transferrin and higher levels of the 4F2 activation Ag. Although T cell responses to suboptimal concentrations of IL-7 were enhanced by the addition of IL-2, the proliferative response to IL-7 was not inhibited by neutralizing antibody to the IL-2R (Tac), nor was IL-2 secretion detected in this response. This response pattern of mature T cells suggests an important role for IL-7 in normal T cell physiology in humans.
白细胞介素-7是一种造血生长因子，可诱导早期B淋巴细胞增殖。在确定其对人骨髓细胞作用的研究过程中，我们注意到成熟T细胞显著增生。当将循环中的T细胞与白细胞介素-7一起培养时，观察到剂量依赖性增殖反应。靶细胞包括T细胞的CD4+和CD8+亚群，但记忆T细胞（CD45R-）比未致敏T细胞（CD45R+）反应更好。白细胞介素-7诱导白细胞介素-2和转铁蛋白受体的表达以及更高水平的4F2激活抗原。虽然添加白细胞介素-2可增强T细胞对次优浓度白细胞介素-7的反应，但对白细胞介素-7的增殖反应并未被白细胞介素-2受体（Tac）的中和抗体抑制，且在此反应中未检测到白细胞介素-2的分泌。成熟T细胞的这种反应模式表明白细胞介素-7在人类正常T细胞生理学中具有重要作用。
