利用白细胞介素-7调节T细胞稳态：临床前和临床研究
Modulating T-cell homeostasis with IL-7: preclinical and clinical studies.
作者信息
Capitini C M, Chisti A A, Mackall C L
机构信息
Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
J Intern Med. 2009 Aug;266(2):141-53. doi: 10.1111/j.1365-2796.2009.02085.x.
Abstract
Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.
摘要
白细胞介素-7（IL-7）是T细胞发育和存活所必需的，在调节T细胞内环境稳定方面发挥着关键作用。本综述将阐述目前对IL-7生物学的理解，回顾近期的临床经验，并讨论IL-7或IL-7阻断在疾病背景下潜在的未来临床应用。
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