心脏毒性在食管癌放射治疗中是一个相关问题吗？
Is cardiac toxicity a relevant issue in the radiation treatment of esophageal cancer?
作者信息
Beukema Jannet C, van Luijk Peter, Widder Joachim, Langendijk Johannes A, Muijs Christina T
机构信息
Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
出版信息
Radiother Oncol. 2015 Jan;114(1):85-90. doi: 10.1016/j.radonc.2014.11.037. Epub 2014 Dec 30.
PURPOSE
In recent years several papers have been published on radiation-induced cardiac toxicity, especially in breast cancer patients. However, in esophageal cancer patients the radiation dose to the heart is usually markedly higher. To determine whether radiation-induced cardiac toxicity is also a relevant issue for this group, we conducted a review of the current literature.
METHODS
A literature search was performed in Medline for papers concerning cardiac toxicity in esophageal cancer patients treated with radiotherapy with or without chemotherapy.
RESULTS
The overall crude incidence of symptomatic cardiac toxicity was as high as 10.8%. Toxicities corresponded with several dose-volume parameters of the heart. The most frequently reported complications were pericardial effusion, ischemic heart disease and heart failure.
CONCLUSION
Cardiac toxicity is a relevant issue in the treatment of esophageal cancer. However, valid Normal Tissue Complication Probability models for esophageal cancer are not available at present.
目的
近年来，已有多篇关于辐射诱发心脏毒性的论文发表，尤其是在乳腺癌患者中。然而，在食管癌患者中，心脏所接受的辐射剂量通常明显更高。为了确定辐射诱发的心脏毒性对该群体而言是否也是一个相关问题，我们对当前文献进行了综述。
方法
在医学在线数据库（Medline）中进行文献检索，查找有关接受放疗（无论是否联合化疗）的食管癌患者心脏毒性的论文。
结果
有症状的心脏毒性的总体粗发病率高达10.8%。毒性与心脏的几个剂量 - 体积参数相关。最常报告的并发症是心包积液、缺血性心脏病和心力衰竭。
结论
心脏毒性在食管癌治疗中是一个相关问题。然而，目前尚无适用于食管癌的有效的正常组织并发症概率模型。
Zotero 插件