多能性、分化和重编程过程中的RNA结合蛋白
RNA-binding proteins in pluripotency, differentiation, and reprogramming.
作者信息
Guallar Diana, Wang Jianlong
机构信息
The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
出版信息
Front Biol (Beijing). 2014 Oct;9(5):389-409. doi: 10.1007/s11515-014-1326-y.
Embryonic stem cell maintenance, differentiation, and somatic cell reprogramming require the interplay of multiple pluripotency factors, epigenetic remodelers, and extracellular signaling pathways. RNA-binding proteins (RBPs) are involved in a wide range of regulatory pathways, from RNA metabolism to epigenetic modifications. In recent years we have witnessed more and more studies on the discovery of new RBPs and the assessment of their functions in a variety of biological systems, including stem cells. We review the current studies on RBPs and focus on those that have functional implications in pluripotency, differentiation, and/or reprogramming in both the human and mouse systems.
胚胎干细胞的维持、分化以及体细胞重编程需要多种多能性因子、表观遗传重塑因子和细胞外信号通路之间的相互作用。RNA结合蛋白（RBPs）参与了从RNA代谢到表观遗传修饰的广泛调控途径。近年来，我们目睹了越来越多关于发现新的RBPs以及评估它们在包括干细胞在内的各种生物系统中的功能的研究。我们综述了目前关于RBPs的研究，并重点关注那些在人类和小鼠系统中对多能性、分化和/或重编程具有功能影响的RBPs。
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