Greenberg A J, Philip S, Paner A, Velinova S, Badros A, Catchatourian R, Ketterling R, Kyle R A, Kumar S, Vachon C M, Rajkumar S V
Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA.
University of Maryland, Baltimore, MD, USA.
Blood Cancer J. 2015 Jan 2;5(1):e271. doi: 10.1038/bcj.2014.91.
We examined four clinically assessed cytogenetic subtypes (t(11;14), t(4;14), monosomy 13/del13q and monosomy 17/del17p in 292 black patients with newly diagnosed multiple myeloma (MM) from four medical centers, who had fluorescent in situ hybridization testing results available in their medical records. We then compared the prevalence of these abnormalities with a previously characterized Mayo Clinic cohort of 471 patients with MM. We found a significant difference in the prevalence of the t(11;14) immunoglobulin heavy chain (IgH) translocation between blacks and whites, 6.5% versus 17.6%, respectively, P<0.0001. Blacks also had lower rates of the t(4;14) IgH translocation, (5.5% versus 10%); monosomy 13/del13q (29.1 versus 49.3%); and monosomy 17/del17p (7.9% versus 13%). Consequently, 63.4% of blacks versus 34.6% of whites did not have any of the four abnormalities that we studied, P<0.001. As almost all MM is associated with either an IgH translocation or trisomies, we hypothesize that MM in blacks is associated with either excess prevalence of either the trisomic (hyperdiploid) form of MM or an IgH translocation besides t(11;14) or t(4;14). We conclude that there are significant differences in the cytogenetic subtypes of MM that occur in blacks and whites.
我们检测了来自四个医疗中心的292例新诊断的黑人多发性骨髓瘤（MM）患者的四种经临床评估的细胞遗传学亚型（t(11;14)、t(4;14)、13号染色体单体/13q缺失和17号染色体单体/17p缺失），这些患者的病历中有荧光原位杂交检测结果。然后，我们将这些异常的患病率与之前在梅奥诊所确定特征的471例MM患者队列进行了比较。我们发现，黑人与白人之间t(11;14)免疫球蛋白重链（IgH）易位的患病率存在显著差异，分别为6.5%和17.6%，P<0.0001。黑人中t(4;14) IgH易位的发生率也较低（5.5%对10%）；13号染色体单体/13q缺失（29.1%对49.3%）；以及17号染色体单体/17p缺失（7.9%对13%）。因此，63.4%的黑人与34.6%的白人没有我们所研究的四种异常中的任何一种，P<0.001。由于几乎所有的MM都与IgH易位或三体性相关，我们推测黑人的MM与MM的三体（超二倍体）形式的患病率过高或除t(11;14)或t(4;14)之外的IgH易位有关。我们得出结论，黑人和白人中发生的MM细胞遗传学亚型存在显著差异。
