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种族差异、癌症与对氧化应激的反应。

Racial disparities, cancer and response to oxidative stress.

机构信息

Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States.

Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States.

出版信息

Adv Cancer Res. 2019;144:343-383. doi: 10.1016/bs.acr.2019.03.012. Epub 2019 Apr 23.

Abstract

At the intersection of genetics, biochemistry and behavioral sciences, there is a largely untapped opportunity to consider how ethnic and racial disparities contribute to individual sensitivity to reactive oxygen species and how these might influence susceptibility to various cancers and/or response to classical cancer treatment regimens that pervasively result in the formation of such chemical species. This chapter begins to explore these connections and builds a platform from which to consider how the disciplines can be strengthened further.

摘要

在遗传学、生物化学和行为科学的交叉点上,有一个很大的未开发的机会,可以考虑种族和民族差异如何导致个体对活性氧物种的敏感性,以及这些差异如何影响对各种癌症的易感性和/或对经典癌症治疗方案的反应,这些方案普遍导致这些化学物质的形成。本章开始探讨这些联系,并建立一个平台,从中考虑如何进一步加强这些学科。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/519e/7104807/78ae629fea01/nihms-1571194-f0001.jpg

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