Department of Maxillofacial Tissue Regeneration, School of Dentistry and Institute of Oral Biology, Kyung Hee University, Seoul, Republic of Korea.
Department of Periodontology, School of Dentistry, Dankook University, Cheonan, Republic of Korea.
Arch Oral Biol. 2015 Mar;60(3):496-500. doi: 10.1016/j.archoralbio.2014.12.003. Epub 2014 Dec 23.
Angiotensin-converting enzyme (ACE) is the core enzyme in the renin-angiotensin system (RAS), which catalyzes the production of angiotensin II (Ang II). The aim of this study was to determine whether ACE gene is associated with the development of the periodontal disease.
To investigate whether ACE is involved in the development of the periodontal disease, 199 periodontal disease patients and 165 control subjects were studied. The ACE insertion/deletion polymorphism was analyzed using polymerase chain reaction (PCR). SNPStats and SPSS 18.0 were used for the analysis of genetic data. Logistic regression models were performed to determine odds ratio (OR), 95% confidence interval (CI), and P value.
Genotypic frequencies of I/I, I/D, and D/D were 25.4%, 42.3%, and 32.3% vs. 35.3%, 41.7%, and 23.1% (periodontal disease group vs. control group), respectively. In the genotype analysis of the ACE insertion/deletion polymorphism, codominant and log-additive models both showed significant association with periodontal disease [OR = 1.94, 95% CI = 1.05-3.61, P=0.036 in the codominant model (I/I vs. D/D); OR = 1.39, 95% CI = 1.02-1.90, P = 0.034 in the log-additive model (I/I vs. I/D vs. D/D)].
These results suggest that the ACE insertion/deletion polymorphism may be associated with the susceptibility to the periodontal disease in the Korean population.
血管紧张素转换酶（ACE）是肾素-血管紧张素系统（RAS）的核心酶，可催化血管紧张素 II（Ang II）的产生。本研究旨在确定 ACE 基因是否与牙周病的发生有关。
为了探讨 ACE 是否参与牙周病的发生，研究了 199 例牙周病患者和 165 例对照者。采用聚合酶链反应（PCR）分析 ACE 插入/缺失多态性。使用 SNPStats 和 SPSS 18.0 分析遗传数据。采用 logistic 回归模型确定比值比（OR）、95%置信区间（CI）和 P 值。
I/I、I/D 和 D/D 基因型频率分别为 25.4%、42.3%和 32.3%，而牙周病组和对照组分别为 35.3%、41.7%和 23.1%。ACE 插入/缺失多态性的基因型分析中，显性和加性模型均与牙周病显著相关[OR=1.94，95%CI=1.05-3.61，P=0.036（显性模型，I/I 与 D/D 比较）；OR=1.39，95%CI=1.02-1.90，P=0.034（加性模型，I/I 与 I/D 与 D/D 比较）]。
这些结果表明，ACE 插入/缺失多态性可能与韩国人群牙周病的易感性有关。
