白细胞介素-1 基因多态性（rs16944）与慢性牙周炎之间缺乏关联：病例对照研究的更新荟萃分析。
Lack of Association between Interleukin-1 Gene Polymorphism (rs16944) and Chronic Periodontitis: From a Case-Control Studies to an Updated Meta-Analysis.
机构信息
Department of Prosthodontics, Kyung Hee University Dental Hospital, Seoul, Republic of Korea.
Department of Dental Pharmacology, College of Dentistry, Dankook University, Cheonan, Republic of Korea.
出版信息
Dis Markers. 2018 Dec 11;2018:8287026. doi: 10.1155/2018/8287026. eCollection 2018.
BACKGROUND
Interleukin-1 (IL-1) plays an important role as a mediator of various inflammatory responses in chronic periodontitis. Several studies have investigated the potential relationship between IL-1 polymorphism (rs16944) and susceptibility to chronic periodontitis; inflammatory process is involved, but conclusions is still controversial.
OBJECTIVE
The aim of this study was to determine whether the IL-1 polymorphism (rs16944) is associated with susceptibility to chronic periodontitis.
MATERIAL AND METHODS
For the case-control study, 51 patients with chronic periodontitis and 33 healthy control patients were recruited in the study. Genotyping was conducted by direct sequencing. SNPStats and SPSS 18.0 were used for the analysis of genetic data and to evaluate odds ratios, 95% confidence intervals, and values; logistic regression models were used. And to perform meta-analysis, studies about IL-1 polymorphism (rs16944) and chronic periodontitis were searched in PubMed, Embase, Google Scholar, and Korean Studies Information Service System (KISS) electronic databases until July 2017.
RESULTS
In our case-control study, no significant relationship was revealed between IL-1 polymorphism (rs16944) and chronic periodontitis ( > 0.05 in each model). When combined with the previous studies in the meta-analysis, the result was not associated with chronic periodontitis in any of the models (CC vs. CT + TT: OR = 0.97, 95% CI = 0.762-1.246; CC + CT vs. TT: OR = 0.90, 95% CI = 0.658-1.232; and C vs. T: OR = 0.93, 95% CI = 0.774-1.128). The subgroup analysis stratified by ethnicity showed a weak association between the IL-1 polymorphism (rs16944) and chronic periodontitis in the Caucasian population (recessive model, OR = 1.34, 95% CI = 1.017-1.758, = 0.037).
CONCLUSION
Evidences from a case-control study and the meta-analysis suggest that IL-1 polymorphism (rs16944) is not associated with susceptibility to chronic periodontitis.
背景
白细胞介素-1（IL-1）作为慢性牙周炎中各种炎症反应的重要介质发挥作用。有几项研究调查了白细胞介素-1 多态性（rs16944）与慢性牙周炎易感性之间的潜在关系；炎症过程涉及其中，但结论仍存在争议。
目的
本研究旨在确定白细胞介素-1 多态性（rs16944）是否与慢性牙周炎的易感性相关。
材料和方法
在这项病例对照研究中，招募了 51 名慢性牙周炎患者和 33 名健康对照患者。通过直接测序进行基因分型。使用 SNPStats 和 SPSS 18.0 分析遗传数据，并评估比值比、95%置信区间和 值；使用逻辑回归模型。为了进行荟萃分析，在 2017 年 7 月之前，在 PubMed、Embase、Google Scholar 和韩国研究信息服务系统（KISS）电子数据库中搜索了关于白细胞介素-1 多态性（rs16944）和慢性牙周炎的研究。
结果
在我们的病例对照研究中，白细胞介素-1 多态性（rs16944）与慢性牙周炎之间未显示出显著相关性（在每种模型中均>0.05）。当与荟萃分析中的先前研究相结合时，结果在任何模型中均与慢性牙周炎无关（CC 与 CT+TT：OR=0.97，95%CI=0.762-1.246；CC+CT 与 TT：OR=0.90，95%CI=0.658-1.232；C 与 T：OR=0.93，95%CI=0.774-1.128）。按种族分层的亚组分析表明，白细胞介素-1 多态性（rs16944）与白种人群的慢性牙周炎之间存在弱相关性（隐性模型，OR=1.34，95%CI=1.017-1.758，=0.037）。
结论
病例对照研究和荟萃分析的证据表明，白细胞介素-1 多态性（rs16944）与慢性牙周炎的易感性无关。
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