Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China.
Department of Thoracic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China.
Thromb Res. 2015 Mar;135(3):459-63. doi: 10.1016/j.thromres.2014.12.016. Epub 2014 Dec 23.
Epidemiological studies evaluating the association of flavonoids intake with risk of coronary heart disease (CHD) have produced inconsistent results. We conducted a meta-analysis to summarize the evidence from prospective cohort studies regarding the association between flavonoids intake and risk of CHD.
Pertinent studies were identified by searching Web of Knowledge, Pubmed and Wan Fang Med Online up to April 2014. Fixed-effect or random-effect model was used to combine the results based on the heterogeneity. Dose-response relationship was assessed by restricted cubic spline. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test.
Fourteen articles with 15 prospective studies involving 7,233 CHD cases and 452,564 participants were included in this meta-analysis. Pooled results suggested that highest flavonoids intake versus lowest intake was significantly associated with the risk of CHD [summary relative risk (RR) = 0.850, 95% confidence interval (CI) = 0.794-0.910, I(2) = 26.0%, τ(2) = 0.041]. Inverse associations were found both in Europe and in USA. Linear dose-response relationship was found between flavonoids intake and CHD risk. However, no significant association was found through the dose-response analysis (an increment of 20 mg/day, summary incidence rate ratios (IRR) = 0.95, 95%CI = 0.88-1.02).
Our results from this meta-analysis suggested that elevated flavonoids intake might have a protective effect on CHD.
评估黄酮类化合物摄入量与冠心病（CHD）风险之间关联的流行病学研究结果并不一致。我们进行了一项荟萃分析，以总结关于黄酮类化合物摄入量与 CHD 风险之间关联的前瞻性队列研究的证据。
通过搜索 Web of Knowledge、Pubmed 和 Wan Fang Med Online，截至 2014 年 4 月，确定了相关研究。根据异质性，使用固定效应或随机效应模型来合并结果。使用限制性立方样条评估剂量-反应关系。使用 Begg 漏斗图和 Egger 回归不对称检验估计发表偏倚。
本荟萃分析纳入了 14 篇文章，共涉及 15 项前瞻性研究，包括 7233 例 CHD 病例和 452564 名参与者。汇总结果表明，最高黄酮类化合物摄入量与最低摄入量相比，与 CHD 风险显著相关[汇总相对风险（RR）=0.850，95%置信区间（CI）=0.794-0.910，I²=26.0%，τ²=0.041]。在欧洲和美国都发现了相反的关联。黄酮类化合物摄入量与 CHD 风险之间存在线性剂量-反应关系。然而，通过剂量-反应分析未发现显著关联（每天增加 20 毫克，汇总发生率比（IRR）=0.95，95%CI=0.88-1.02）。
本荟萃分析的结果表明，黄酮类化合物摄入量的增加可能对 CHD 具有保护作用。
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