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[前路及前外侧入路治疗胸腰椎椎体转移瘤致脊髓压迫症]

[Anterior and anterolateral approach in the treatment of thoracic and lumbar vertebral metastasis causing spinal cord compression].

作者信息

Vargas López Antonio José, Fernández Carballal Carlos, Panadero Useros Teresa, Aracil González Cristina, Garbizu Vidorreta José Manuel, González Rodrigálvarez Rosario

机构信息

Servicio de Neurocirugía, Hospital General Universitario Gregorio Marañón, Madrid, España.

Servicio de Neurocirugía, Hospital General Universitario Gregorio Marañón, Madrid, España.

出版信息

Neurocirugia (Astur). 2015 May-Jun;26(3):126-36. doi: 10.1016/j.neucir.2014.11.003. Epub 2014 Dec 30.

Abstract

OBJECTIVES

To analyse the results of the anterior and anterolateral approaches in the treatment of thoracic and lumbar spine metastasis.

MATERIALS AND METHODS

Patients who underwent surgery between 2003 and 2012 in our institution using an anterior or an anterolateral approach for the treatment of thoracic or lumbar spine metastasis were retrospectively reviewed.

RESULTS

Twenty-two patients with median age of 49.5 years (26-73 years) and median follow-up of 9.5 months (0-96 months) were analysed. The most common primary malignancies were renal cell carcinomas and breast adenocarcinomas. Before the intervention, 12 (54.5%) patients were able to walk (Frankel D and E). Preoperative arteriography was performed in 14 (63.6%) patients, and 7 (31.8%) of them underwent tumour embolisation. Medical complications occurred in 5 (22.7%) patients during the immediate postoperative period, 2 (9.1%) of whom died. At the end of follow-up, 16 (72%) of the remaining 20 patients were able to walk (Frankel D and E). Ninety percent of the patients could reduce at least 50% of their analgesic drug requirements. During follow-up 16 patients died, with a median survival of 10 months (range 0-48 months).

CONCLUSIONS

Resection of thoracolumbar vertebral metastases by an anterior/anterolateral approach, despite its considerable risk of morbidity and mortality, offers the possibility of significant improvement in the quality of life of the patient; and it does so not only by preserving or restoring their ability to walk but also by ameliorating pain. Preoperative angiography, considering the embolisation of the lesion, is an important tool.

摘要

目的

分析前路及前外侧入路治疗胸腰椎脊柱转移瘤的效果。

材料与方法

回顾性分析2003年至2012年在我院采用前路或前外侧入路治疗胸腰椎脊柱转移瘤的患者。

结果

分析了22例患者,中位年龄49.5岁(26 - 73岁),中位随访时间9.5个月(0 - 96个月)。最常见的原发恶性肿瘤为肾细胞癌和乳腺腺癌。干预前,12例(54.5%)患者能够行走(Frankel D级和E级)。14例(63.6%)患者术前行动脉造影,其中7例(31.8%)接受了肿瘤栓塞。5例(22.7%)患者在术后即刻出现医疗并发症,其中2例(9.1%)死亡。随访结束时,其余20例患者中有16例(72%)能够行走(Frankel D级和E级)。90%的患者至少可减少50%的镇痛药用量。随访期间16例患者死亡,中位生存期为10个月(范围0 - 48个月)。

结论

前路/前外侧入路切除胸腰椎椎体转移瘤,尽管有相当高的发病和死亡风险,但仍有可能显著改善患者生活质量;不仅通过保留或恢复其行走能力,还通过减轻疼痛来实现。考虑对病变进行栓塞的术前血管造影是一项重要工具。

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