犬甲状腺功能减退症中血清脂联素浓度升高。

Increased serum concentrations of adiponectin in canine hypothyroidism.

作者信息

Mazaki-Tovi Michal, Abood Sarah K, Kol Amir, Farkas Amnon, Schenck Patricia A

机构信息

Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot, 76100, Israel.

The Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.

出版信息

Vet J. 2015 Feb;203(2):253-5. doi: 10.1016/j.tvjl.2014.12.007. Epub 2014 Dec 12.

DOI:10.1016/j.tvjl.2014.12.007

PMID:25555336

Abstract

Serum concentrations of adiponectin were compared between sex-matched hypothyroid (n = 18) and euthyroid (n = 18) client-owned dogs with comparable ages and body condition scores (BCS). Concentrations of adiponectin (mean; 95% confidence interval) were significantly (P < 0.01) higher in hypothyroid (17.2 µg/mL; 12.1-20.5 µg/mL) than healthy (8.0 µg/mL; 5.6-11.4 µg/mL) dogs following adjustment for potential confounders (BCS, age and sex). Serum concentrations of adiponectin were significantly negatively associated with concentrations of total thyroxine (P <0.05) and positively correlated with concentrations of cholesterol (r = 0.6, P <0.01) in hypothyroid dogs. In conclusion, this study demonstrated increased serum concentrations of adiponectin in dogs with hypothyroidism. Suggestive of the presence of resistance to adiponectin that could have contributed to development of hyperlipidemia and insulin resistance in these dogs or alternatively, could be a consequence of these metabolic alterations.

摘要

对年龄和身体状况评分（BCS）相当的性别匹配的甲状腺功能减退（n = 18）和甲状腺功能正常（n = 18）的宠物犬的血清脂联素浓度进行了比较。在对潜在混杂因素（BCS、年龄和性别）进行调整后，甲状腺功能减退犬（17.2µg/mL；12.1 - 20.5µg/mL）的脂联素浓度（平均值；95%置信区间）显著（P < 0.01）高于健康犬（8.0µg/mL；5.6 - 11.4µg/mL）。在甲状腺功能减退犬中，血清脂联素浓度与总甲状腺素浓度显著负相关（P < 0.05），与胆固醇浓度正相关（r = 0.6，P < 0.01）。总之，本研究表明甲状腺功能减退犬的血清脂联素浓度升高。提示存在脂联素抵抗，这可能导致这些犬发生高脂血症和胰岛素抵抗，或者是这些代谢改变的结果。