ω-3多不饱和脂肪酸和身体状况对健康犬血清脂肪因子浓度的影响。
Effect of omega-3 polyunsaturated fatty acids and body condition on serum concentrations of adipokines in healthy dogs.
作者信息
Mazaki-Tovi Michal, Abood Sarah K, Schenck Patricia A
机构信息
Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA.
出版信息
Am J Vet Res. 2012 Aug;73(8):1273-81. doi: 10.2460/ajvr.73.8.1273.
OBJECTIVE
To determine associations between serum concentrations of omega-3 polyunsaturated fatty acids or body condition and serum concentrations of adiponectin, leptin, insulin, glucose, or triglyceride in healthy dogs.
ANIMALS
62 healthy adult client-owned dogs.
PROCEDURES
Body condition score and percentage of body fat were determined. Blood samples were collected after food was withheld for 12 hours. Serum was harvested for total lipid determination, fatty acid analysis, and measurement of serum concentrations of adiponectin, leptin, insulin, glucose, and triglyceride. Associations between the outcome variables (adiponectin, leptin, insulin, glucose, and triglyceride concentrations) and each of several variables (age, sex, percentage of body fat, and concentrations of total lipid, α-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) were determined.
RESULTS
Serum concentrations of docosapentaenoic acid were significantly positively associated with concentrations of adiponectin and leptin and negatively associated with concentrations of triglyceride. Serum concentrations of α-linolenic acid were significantly positively associated with concentrations of triglyceride. No significant associations were detected between serum concentrations of eicosapentaenoic acid or docosahexaenoic acid and any of the outcome variables. Percentage of body fat was significantly positively associated with concentrations of leptin, insulin, and triglyceride but was not significantly associated with adiponectin concentration. Age was positively associated with concentrations of leptin, insulin, and triglyceride and negatively associated with concentrations of adiponectin. Sex did not significantly affect serum concentrations for any of the outcome variables.
CONCLUSIONS AND CLINICAL RELEVANCE
Docosapentaenoic acid may increase serum concentrations of adiponectin and leptin and decrease serum triglyceride concentration in healthy dogs.
目的
确定健康犬血清中ω-3多不饱和脂肪酸浓度或身体状况与脂联素、瘦素、胰岛素、葡萄糖或甘油三酯血清浓度之间的关联。
动物
62只健康成年宠物犬。
方法
测定身体状况评分和体脂百分比。禁食12小时后采集血样。收集血清用于总脂质测定、脂肪酸分析以及脂联素、瘦素、胰岛素、葡萄糖和甘油三酯血清浓度的测量。确定结果变量（脂联素、瘦素、胰岛素、葡萄糖和甘油三酯浓度）与几个变量（年龄、性别、体脂百分比以及总脂质、α-亚麻酸、二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸浓度）之间的关联。
结果
二十二碳五烯酸的血清浓度与脂联素和瘦素浓度显著正相关，与甘油三酯浓度负相关。α-亚麻酸的血清浓度与甘油三酯浓度显著正相关。未检测到二十碳五烯酸或二十二碳六烯酸的血清浓度与任何结果变量之间存在显著关联。体脂百分比与瘦素、胰岛素和甘油三酯浓度显著正相关，但与脂联素浓度无显著关联。年龄与瘦素、胰岛素和甘油三酯浓度正相关，与脂联素浓度负相关。性别对任何结果变量的血清浓度均无显著影响。
结论及临床意义
二十二碳五烯酸可能会增加健康犬血清中脂联素和瘦素的浓度，并降低血清甘油三酯浓度。
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