阪崎肠杆菌属和大肠杆菌密切相关的O抗原的结构与遗传关系：阪崎肠杆菌G2594（血清型O4）/大肠杆菌O103以及丙二酸肠杆菌G3864（血清型O1）/大肠杆菌O29 。
Structural and genetic relationships of closely related O-antigens of Cronobacter spp. and Escherichia coli: C. sakazakii G2594 (serotype O4)/E. coli O103 and C. malonaticus G3864 (serotype O1)/E. coli O29.
作者信息
Shashkov Alexander S, Wang Min, Turdymuratov Eldar M, Hu Shaohui, Arbatsky Nikolay P, Guo Xi, Wang Lei, Knirel Yuriy A
机构信息
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation.
TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin 300457, China; Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China.
出版信息
Carbohydr Res. 2015 Mar 2;404:124-31. doi: 10.1016/j.carres.2014.11.014. Epub 2014 Dec 13.
O-Antigen (O-polysaccharide) variation is the basis for bacterial serotyping and is important in bacterial virulence and niche adaptation. In this work, we present structural and genetic evidences for close relationships between the O-antigens of the Cronobacter spp. and Escherichia coli. Cronobacter sakazakii G2594 (serotype O4) and Cronobacter malonaticus G3864 (serotype O1) are structurally related to those of E. coli O103 and O29, respectively, and some other members of the Enterobacteriaceae family differing in the patterns of lateral glucosylation (C. sakazakii G2594) or O-acetylation (C. malonaticus G3864). The O-antigen gene clusters of the corresponding Cronobacter and E. coli strains contain the same genes with high-level similarity, and the structural differences within both O-antigen pairs were suggested to be due to modification genes carried by prophages.
O抗原（O-多糖）变异是细菌血清分型的基础，在细菌毒力和生态位适应方面具有重要意义。在本研究中，我们提供了关于阪崎肠杆菌属和大肠杆菌O抗原之间密切关系的结构和遗传学证据。阪崎克罗诺杆菌G2594（血清型O4）和丙二酸克罗诺杆菌G3864（血清型O1）在结构上分别与大肠杆菌O103和O29相关，肠杆菌科的其他一些成员在侧向糖基化模式（阪崎克罗诺杆菌G2594）或O-乙酰化模式（丙二酸克罗诺杆菌G3864）上存在差异。相应的克罗诺杆菌和大肠杆菌菌株的O抗原基因簇包含具有高度相似性的相同基因，并且这两对O抗原内部的结构差异被认为是由前噬菌体携带的修饰基因所致。
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