Klosinski Michal, Tomaszewski Krzysztof A, Wrobel Andrzej, Piech Krzysztof, Skrzat Janusz, Klosinski Piotr, Walocha Jerzy A
Department of Traumatology and Neuroorthopaedics, Rydygier Specialistic Hospital, Department of Anatomy Jagiellonian University Medical College, Krakow, Poland.
Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
Folia Med Cracov. 2013;53(4):13-20.
The aim of this study was to assess the prevalence, clinical features and distribution of lumbosacral ossifications of the ligamentum flavum (OLF), using MRI, CT and microCT, in hospitalized Polish patients.
Patients were recruited prospectively between January 2011 and January 2013. Patients were further qualified to the study group only if CT or MRI of the lumbosacral region detected OLF. Level of OLF excision was determined by the localization of spinal stenosis. After excision the LF fragments containing OLF were stored in a 4% solution of formaldehyde until microCT assessment.
A total of 184 agreed to take part in the study. In 50 patients (27.2%) OLF were found. Thus, the study group consisted of 17 women (34%) and 33 men, with a mean age of 55.4 ± 17.2 years. OLF occurred more often in men (66%) than in women (34%) (p = 0.0014). The most common site for the localization of OLF in women, as well as in men was the L5/S1 level (60% and 53.3% respectively). The mean volume of OLF was 3.87 ± 5.27 mm3 (4.66 ± 5.71 mm3 vs. 1.27 ± 2.19 mm3, in men and women respectively; p = 0.023). The LF were thickened in 21 (42%) patients. The mean volume of OLF in patients with normal LF was 4.78 ± 5.95 mm3 and in patients with thickened LF 5.33 ± 6.10 mm3 (p = 0.75).
The prevalence of lumbosacral OLF in the Polish hospitalized population is very high. The most common site of their localization is the L5/S1 level. LF thickening is not associated with OLF formation.
本研究旨在利用磁共振成像（MRI）、计算机断层扫描（CT）和显微计算机断层扫描（microCT）评估波兰住院患者腰骶部黄韧带骨化（OLF）的患病率、临床特征及分布情况。
于2011年1月至2013年1月前瞻性招募患者。仅当腰骶部CT或MRI检测到OLF时，患者才被纳入研究组。根据椎管狭窄的定位确定OLF切除水平。切除后，将含有OLF的黄韧带碎片保存在4%的甲醛溶液中，直至进行显微CT评估。
共有184名患者同意参与研究。50名患者（27.2%）发现有OLF。因此，研究组包括17名女性（34%）和33名男性，平均年龄为55.4±17.2岁。OLF在男性中的发生率（66%）高于女性（34%）（p = 0.0014）。女性和男性中OLF最常见的定位部位均为L5/S1水平（分别为60%和53.3%）。OLF的平均体积为3.87±5.27立方毫米（男性为4.66±5.71立方毫米，女性为1.27±2.19立方毫米；p = 0.023）。21名（42%）患者的黄韧带增厚。黄韧带正常的患者中OLF的平均体积为4.78±5.95立方毫米，黄韧带增厚的患者中OLF的平均体积为5.33±6.10立方毫米（p = 0.75）。
波兰住院人群中腰骶部OLF的患病率非常高。其最常见的定位部位是L5/S1水平。黄韧带增厚与OLF形成无关。
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