Ullah Khan Mueen, Aqil Mansoor, Hussain Altaf, Al Zahrani Tariq, Hillis Marwan
Department of Anesthesia, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Saudi J Anaesth. 2015 Jan;9(1):9-11. doi: 10.4103/1658-354X.146252.
Tramadol is an atypical analgesic agent. It has been shown that intramuscular or intravenous injection tramadol is able to inhibit M3 muscarinic receptors. Tramadol is able to mediate smooth muscles contraction and glandular secretions. We have evaluated the effects of single oral dose of tramadol given preoperatively on gastric juices pH in patients electively scheduled for laparoscopic cholecystectomy.
Sixty adult, American Society of Anesthesiologist I and II patients scheduled for laparoscopic cholecystectomy were included in the study. Patients were randomly assigned to receive either placebo (n = 30) or oral tramadol 50 mg (n = 30). General anesthesia was induced using propofol, fentanyl and cisatracurium. After induction of anesthesia 5 ml of gastric fluid was aspirated through orogastric tube. The gastric fluid pH was measured using pH meter.
There was no significant difference in the pH between the groups. Gastric pH of the placebo and tramadol groups was 1.97 versus 1.98 (P = 0.092) respectively.
Preoperatively single oral dose of tramadol was unable to elevate the desired level of gastric acid secretions pH (>2.5). This may be due to pharmacokinetic disparity between the analgesic and pH elevating properties of tramadol.
曲马多是一种非典型镇痛药。已表明肌内或静脉注射曲马多能够抑制M3毒蕈碱受体。曲马多能够介导平滑肌收缩和腺体分泌。我们评估了术前单次口服曲马多对择期行腹腔镜胆囊切除术患者胃液pH值的影响。
本研究纳入了60例计划行腹腔镜胆囊切除术的成年美国麻醉医师协会I级和II级患者。患者被随机分配接受安慰剂（n = 30）或口服曲马多50 mg（n = 30）。使用丙泊酚、芬太尼和顺式阿曲库铵诱导全身麻醉。麻醉诱导后，通过口胃管抽取5 ml胃液。使用pH计测量胃液pH值。
两组之间的pH值无显著差异。安慰剂组和曲马多组的胃pH值分别为1.97和1.98（P = 0.092）。
术前单次口服曲马多无法将胃酸分泌pH值提高到所需水平（>2.5）。这可能是由于曲马多的镇痛特性和提高pH值特性之间的药代动力学差异所致。
