Reeves Roy R, Cox Sera K
Department of Mental Health, G.V. (Sonny) Montgomery VA Medical Center, Jackson, Mississippi 39216, USA.
South Med J. 2008 Feb;101(2):193-5. doi: 10.1097/SMJ.0b013e3181616e66.
The analgesic tramadol has many characteristics in common with the antidepressant venlafaxine. The drugs are structurally similar, share both serotonergic and noradrenergic properties, and undergo a similar metabolic fate. In this study, a patient, who developed significant depression following cessation of tramadol after several years of therapy, is described. Her depression was then treated with venlafaxine with excellent response. It appears that tramadol may have provided a prophylactic antidepressant effect in this patient. Because of its similarities to venlafaxine, tramadol may possibly exert a degree of antidepressant effect in certain patients, particularly those with chronic pain.
镇痛药曲马多与抗抑郁药文拉法辛有许多共同特征。这两种药物在结构上相似，都具有5-羟色胺能和去甲肾上腺素能特性，且代谢过程相似。本研究描述了一名患者，其在数年曲马多治疗后停药，出现了严重的抑郁症状。随后用文拉法辛对其抑郁进行治疗，效果良好。在该患者中，曲马多似乎起到了预防性抗抑郁作用。由于曲马多与文拉法辛相似，它可能在某些患者，尤其是慢性疼痛患者中发挥一定程度的抗抑郁作用。
