Park Min-Woo, Cho Young-Ah, Kim Soung-Min, Myoung Hoon, Lee Jong-Ho, Lee Suk-Keun
Department of Oral and Maxillofacial Surgery, Dental Reaserch Institute, Seoul National University, Seoul, Republic of Korea.
Department of Oral and Maxillofacial Pathology, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
J Adv Prosthodont. 2014 Dec;6(6):555-8. doi: 10.4047/jap.2014.6.6.555. Epub 2014 Dec 17.
Focal epithelial hyperplasia (FEH) is a human papillomavirus (HPV)-induced alteration of the oral mucosa that presents with a clinically distinct appearance. While other HPV-infected lesions such as squamous papilloma, verruca vulgaris, and condyloma acuminatum involve the skin, oral mucosa, and genital mucosa, FEH occurs only in the oral mucosa. The affected oral mucosa exhibits multiple papules and nodules with each papule/nodule being flat-topped or sessile. The affected region resembles the normal color of oral mucosa rather than appearing as a white color since the epithelial surface is not hyperkeratinized. Almost all cases present with multiple sites of occurrence. This rare, benign epithelial proliferation is related to low-risk HPV, especially HPV-13 and -32, and is not transformed into carcinoma. We report a case of FEH that arose on the attached gingiva of an East Asian male adult related to prosthesis without detection of any HPV subtype in HPV DNA chip and sequencing.
局灶性上皮增生（FEH）是一种由人乳头瘤病毒（HPV）引起的口腔黏膜病变，具有独特的临床表现。虽然其他HPV感染性病变，如鳞状乳头瘤、寻常疣和尖锐湿疣，可累及皮肤、口腔黏膜和生殖器黏膜，但FEH仅发生于口腔黏膜。受累的口腔黏膜表现为多个丘疹和结节，每个丘疹/结节呈扁平状或无柄状。受累区域颜色与正常口腔黏膜相似，而非白色，因为上皮表面未过度角化。几乎所有病例均为多部位发病。这种罕见的良性上皮增生与低风险HPV有关，尤其是HPV - 13和 - 32，不会恶变。我们报告1例发生于东亚成年男性附着龈的FEH病例，该病例与义齿有关，HPV DNA芯片检测和测序未发现任何HPV亚型。
