不同剂量吡喹酮治疗日本血吸虫病的疗效与安全性：一项系统评价和荟萃分析

Efficacy and safety of different dosages of praziquantel for the treatment of schistosoma japonicum: a systematic review and meta-analysis.

作者信息

Cai Damin, Zhang Si, Wu Julong, Wang Xun, Wang Meng, Lu Xiaoling, Chen Huiyu, Wang Qian, Ma Xingming

机构信息

Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China ; Department of Immunology, School of Basic Medical Sciences, Zhejiang Medical College, Hangzhou, China.

Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou,China.

出版信息

Iran Red Crescent Med J. 2014 Oct 5;16(10):e9600. doi: 10.5812/ircmj.9600. eCollection 2014 Oct.

DOI:10.5812/ircmj.9600

PMID:25558390

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4270676/

Abstract

BACKGROUND

Praziquantel, an antischistosomal compound, is used as first-line drug for chemotherapy of Schistosoma japonicum since 1984. In this article, we conducted a systematic review and mete-analysis to evaluate the efficacy and safety of different dosages of praziquantel (PZQ) for treatment of Schistosoma japonicum.

EVIDENCE ACQUISITION

A number of six articles published in peer-reviewed journals before December 2012 were selected for analysis after searching the following literature databases: PubMed/Medline, the Chinese WanFang Literature Database, China National Knowledge Infrastructure (1994-2012.12), and the Chinese Biomedical Literature (1978-2012.12).

RESULTS

The meta-analyses showed that there is no statistically significant difference of the negative rate on the egg using 40 mg/kg compared to 60 mg/kg PZQ for S. japonicum treatment (RR 0.79, 95% CI 0.46 1.35; P < 0.39). The meta-analysis showed that there is no statistically significant difference of the side effects using 30 mg/kg compared with 40 mg/kg (RR 0.97, 95% CI 0.68 1.38; P = 0.87), 40 mg/kg compared with 60 mg/kg (RR 0.79, 95% CI 0.46 1.35; P = 0.39) and 50 mg/kg compared with 60 mg/kg (RR 0.89, 95% CI 0.56 1.42; P = 0.63).

CONCLUSIONS

According to the results, there is no statistically significant difference in different doses of PZQ for treating S. japonicum.

摘要

背景

吡喹酮是一种抗血吸虫化合物，自1984年以来一直用作日本血吸虫化疗的一线药物。在本文中，我们进行了一项系统评价和荟萃分析，以评估不同剂量吡喹酮（PZQ）治疗日本血吸虫病的疗效和安全性。

证据获取

在检索了以下文献数据库后，选择了2012年12月之前发表在同行评审期刊上的6篇文章进行分析：PubMed/Medline、中国万方文献数据库、中国知网（1994 - 2012.12）和中国生物医学文献数据库（1978 - 2012.12）。

结果

荟萃分析表明，使用40mg/kg吡喹酮与60mg/kg吡喹酮治疗日本血吸虫病时，虫卵阴转率无统计学显著差异（RR 0.79，95%CI 0.46 - 1.35；P < 0.39）。荟萃分析表明，使用30mg/kg与40mg/kg（RR 0.97，95%CI 0.68 - 1.38；P = 0.87）、40mg/kg与60mg/kg（RR 0.79，95%CI 0.46 - 1.35；P = 0.39）以及50mg/kg与60mg/kg（RR 0.89，95%CI 0.56 - 1.42；P = 0.63）时，副作用无统计学显著差异。