南亚头颈部鳞状细胞癌中表皮生长因子受体（EGFR）的免疫组织化学表达：与各种风险因素及临床病理和预后参数的关系。
Immunohistochemical expression of epidermal growth factor receptor (EGFR) in South Asian head and neck squamous cell carcinoma: association with various risk factors and clinico-pathologic and prognostic parameters.
机构信息
Liaquat National Hospital and Medical College, Karachi, Pakistan.
Shaheed Zulfiqar Ali Institute of Science and Technology, Karachi, Pakistan.
出版信息
World J Surg Oncol. 2018 Jun 28;16(1):118. doi: 10.1186/s12957-018-1425-3.
BACKGROUND
In this study, we intend to determine the immunohistochemical expression of EGFR in cases of head and neck squamous cell carcinoma and its association with prognostic clinico-pathologic features.
METHODS
A total of 115 cases of head and neck squamous cell carcinoma treated at Liaquat National Hospital, Karachi, Pakistan, were included in the study. Clinico-pathologic features, risk factors, and recurrence status of cases were evaluated, and EGFR immunohistochemistry was performed.
RESULTS
In our study, 52 cases (45.2%) of head and neck SCC were positive and 10 cases (8.7%) were focal positive for EGFR expression, while 53 cases (46.1%) were negative for EGFR expression. High EGFR expression (> 70%) was noted in 6.1% (7 cases), while 12.2% (14 cases) and 26.1% (30 cases) revealed 51-70% and 11-50% EGFR expression respectively. On the basis of intensity, strong EGFR expression was noted in 13.9% (16 cases) while 16.5% (19 cases) and 23.5% (27 cases) revealed intermediate and weak EGFR expression respectively. Significant association of EGFR expression was noted with tumor stage and disease-free survival.
CONCLUSION
We found a significant association of EGFR expression with tumor stage and disease-free survivals, which are the most important prognostic factors in head and neck squamous cell carcinoma; therefore, EGFR expression can help as a prognostic biomarker in head and neck squamous cell carcinoma. On the other hand, we suggest that molecular studies should be performed in squamous cell carcinoma of head and neck in our setup to identify patients that can avail response from anti-EGFR therapy.
背景
本研究旨在确定头颈部鳞状细胞癌中 EGFR 的免疫组织化学表达及其与预后临床病理特征的关系。
方法
纳入巴基斯坦卡拉奇利亚卡特国家医院治疗的 115 例头颈部鳞状细胞癌患者。评估病例的临床病理特征、危险因素和复发情况，并进行 EGFR 免疫组化检测。
结果
本研究中，52 例（45.2%）头颈部 SCC 患者 EGFR 表达阳性，10 例（8.7%）患者 EGFR 表达局灶阳性，53 例（46.1%）患者 EGFR 表达阴性。高 EGFR 表达（>70%）占 6.1%（7 例），12.2%（14 例）和 26.1%（30 例）患者分别显示 51-70%和 11-50%的 EGFR 表达。根据强度，强 EGFR 表达占 13.9%（16 例），16.5%（19 例）和 23.5%（27 例）患者分别显示中等和弱 EGFR 表达。EGFR 表达与肿瘤分期和无病生存率显著相关。
结论
我们发现 EGFR 表达与肿瘤分期和无病生存率显著相关，这是头颈部鳞状细胞癌最重要的预后因素；因此，EGFR 表达可作为头颈部鳞状细胞癌的预后生物标志物。另一方面，我们建议在我们的研究中对头颈部鳞状细胞癌进行分子研究，以确定能从抗 EGFR 治疗中获益的患者。
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