Chernova A A, Nikulina S Iu, Tret'iakova S S, Maksimov V N, Voevoda M I, Chernov V N
Vestn Ross Akad Med Nauk. 2014(5-6):60-4. doi: 10.15690/vramn.v69i5-6.1045.
The purpose of this study was to investigate association between the genetic polymorphism I/D of gene α2β-adrenoreceptor (ADRA2B) and hereditary disorders of ventricular conduction.
In this study, 102 people with complete left bundle branch block (45.71 ± 1.852 years)--46 females and 56 males, and 86 people with complete right bundle branch block (34.59 ± 1.86 years)--41 females and 45 males. The study was approved by Ethic Committee of the KrasSMU. All participants were included in the study after written informed consent form. Cardiological examination included clinical examination, electrocardiography, echocardiography, Holter monitoring, stress-test, koronaroangiografy and radionuclide method of a myocardium and molecular and genetic researches.
Statistically, significant prevalence of a homozygous genotype of DD on rare allele gene ADRA2B in both groups in comparison with group of control is established. The reliable dominance of the homozygous rare genotypes (D allele) of gene ADRA2B were detected in all groups.
Polymorphism DD of a gene ADRA2B is a genetic predictor of predisposition to the blockade of the right and left bundle branch block.
本研究旨在探讨α2β肾上腺素能受体（ADRA2B）基因的I/D遗传多态性与心室传导遗传性疾病之间的关联。
本研究纳入102例完全性左束支传导阻滞患者（年龄45.71±1.852岁），其中女性46例，男性56例；以及86例完全性右束支传导阻滞患者（年龄34.59±1.86岁），其中女性41例，男性45例。本研究经克拉斯诺亚尔斯克国立医科大学伦理委员会批准。所有参与者在签署书面知情同意书后纳入研究。心脏检查包括临床检查、心电图、超声心动图、动态心电图监测、负荷试验、冠状动脉造影以及心肌放射性核素检查和分子遗传学研究。
统计学分析表明，与对照组相比，两组中ADRA2B基因罕见等位基因的纯合基因型DD的患病率均有显著差异。在所有组中均检测到ADRA2B基因纯合罕见基因型（D等位基因）的可靠显性。
ADRA2B基因的DD多态性是左右束支传导阻滞易感性的遗传预测指标。
