Chernova A A, Nikulina S Iu, Tret'iakova S S, Maksimov V N, Voevoda M I, Chernov V N
Krasnoyarsk State Medical University of prof. V.F. Vojno-Yasenetsky, ul. Partizana Zheleznyaka 1, 660022 Krasnoyarsk, Russia.
Kardiologiia. 2013;53(7):45-9.
The article is devoted to the role of insertion-deletion polymorphism of -2-adrenoreceptor gene in development of hereditary disorders of cardiac conduction. We examined 71 patients with atrioventricular blocks and 92 patients with sick sinus node syndrome. Statistically significant preponderance of homozygous genotype DD of ADRA2B gene was found in both groups. Associations of alleles with male or female gender were also revealed.
本文致力于探讨β2-肾上腺素能受体基因插入缺失多态性在遗传性心脏传导障碍发生发展中的作用。我们研究了71例房室传导阻滞患者和92例病态窦房结综合征患者。在两组患者中均发现ADRA2B基因纯合子基因型DD具有统计学意义的优势。还揭示了等位基因与男性或女性性别的关联。
