Department of Family Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Endocrinol Metab (Seoul). 2014 Dec 29;29(4):479-88. doi: 10.3803/EnM.2014.29.4.479.
Increased serum ferritin and decreased vitamin D levels associated with nonalcoholic fatty liver disease (NAFLD). However, their association with the severity of NAFLD has not been fully evaluated. The aim of this study was to compare the association of serum ferritin and 25(OH)D₃ levels with the severity of ultrasonographically detected NAFLD (US-NAFLD) and hepatic steatosis defined by fatty liver index (FLI) in Korean adults.
A cross-sectional analysis of clinical and anthropometric data, including serum ferritin and 25(OH)D₃, from men (n=295) and women (n=263) who underwent a routine health check-up in 2012.
In men, with an increase in the quartile of serum ferritin level, the incidences of subjects with metabolic syndrome (P=0.002), US-NAFLD (P=0.041), and FLI ≥60 (P=0.010) were significantly elevated. In women, the incidence of subjects with US-NAFLD was also significantly elevated with increases in the serum ferritin quartile (P=0.012). Regarding 25(OH)D₃, no statistical differences were observed among the different quartiles in either gender. Serum ferritin level significantly increased as the severity of US-NAFLD increased (P<0.001); however, no significant differences in 25(OH)D₃ level were observed in men. No significant differences in either serum ferritin or 25(OH)D₃ level were observed among women with different levels of severity of US-NAFLD.
Increased serum ferritin level showed a closer association with severity of NAFLD compared with level of serum vitamin D, suggesting that serum ferritin level may be a better marker than vitamin D level for predicting the severity of US-NAFLD and hepatic steatosis in a clinical setting.
血清铁蛋白升高和维生素 D 水平降低与非酒精性脂肪性肝病（NAFLD）有关。然而，它们与 NAFLD 严重程度的关系尚未得到充分评估。本研究旨在比较血清铁蛋白和 25（OH）D₃水平与韩国成年人超声检测的 NAFLD（US-NAFLD）严重程度和由脂肪肝指数（FLI）定义的肝脂肪变性的相关性。
对 2012 年进行常规健康检查的男性（n=295）和女性（n=263）的临床和人体测量学数据（包括血清铁蛋白和 25（OH）D₃）进行横断面分析。
在男性中，随着血清铁蛋白水平四分位的增加，代谢综合征（P=0.002）、US-NAFLD（P=0.041）和 FLI≥60（P=0.010）的受试者发生率显著升高。在女性中，随着血清铁蛋白四分位的增加，US-NAFLD 的发生率也显著升高（P=0.012）。关于 25（OH）D₃，无论在男性还是女性中，不同四分位之间均无统计学差异。随着 US-NAFLD 严重程度的增加，血清铁蛋白水平显著升高（P<0.001）；然而，在男性中，25（OH）D₃水平没有显著差异。在女性中，无论 US-NAFLD 的严重程度如何，血清铁蛋白或 25（OH）D₃水平均无显著差异。
与血清维生素 D 水平相比，血清铁蛋白水平升高与 NAFLD 的严重程度更密切相关，这表明血清铁蛋白水平可能是预测临床 US-NAFLD 和肝脂肪变性严重程度的更好标志物，而不是维生素 D 水平。
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