Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea.
Diabetes Care. 2012 Dec;35(12):2521-6. doi: 10.2337/dc12-0543. Epub 2012 Aug 28.
Elevated serum ferritin has been known to be associated with the prevalence of metabolic syndrome (MetS). However, there was no research to examine whether serum ferritin levels have been actually associated with the prospective development of MetS. Accordingly, we carried out a prospective study to evaluate the longitudinal effects of baseline serum ferritin levels on the development of MetS.
A MetS-free cohort of 18,022 healthy Korean men, who had participated in a medical health checkup program in 2005, was followed until 2010. MetS was defined according to the joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Cox proportional hazards models were performed.
During 45,919.3 person-years of follow-up, 2,127 incident cases of MetS developed between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95% CI) for incident MetS comparing the second quintile to the fifth quintile of serum ferritin levels versus the first quintile were 1.19 (0.98-1.45), 1.17 (0.96-1.43), 1.36 (1.12-1.65), and 1.66 (1.38-2.01), respectively (P for trend <0.001). These associations were apparent in the clinically relevant subgroup analyses.
Elevated serum ferritin levels were independently associated with future development of MetS during the 5-year follow-up period.
已知血清铁蛋白升高与代谢综合征（MetS）的患病率有关。然而，尚无研究检查血清铁蛋白水平是否与 MetS 的前瞻性发展有关。因此，我们进行了一项前瞻性研究，以评估基线血清铁蛋白水平对 MetS 发展的纵向影响。
对 18022 名参加 2005 年医疗健康检查计划且无 MetS 的韩国男性进行了随访，随访时间截至 2010 年。MetS 根据国际糖尿病联合会流行病学和预防工作组的联合临时声明定义。采用 Cox 比例风险模型进行分析。
在 45919.3 人年的随访期间，2006 年至 2010 年期间发生了 2127 例 MetS 事件。在调整了多个协变量后，与血清铁蛋白水平的第一五分位数相比，第二五分位数至第五五分位数发生 MetS 的风险比（95%CI）分别为 1.19（0.98-1.45）、1.17（0.96-1.43）、1.36（1.12-1.65）和 1.66（1.38-2.01）（趋势 P<0.001）。这些关联在临床相关的亚组分析中也很明显。
在 5 年随访期间，血清铁蛋白水平升高与 MetS 的未来发展独立相关。
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