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1
No relationship between drug transporter genetic variants and tenofovir plasma concentrations or changes in glomerular filtration rate in HIV-infected adults.在感染HIV的成年人中，药物转运体基因变异与替诺福韦血浆浓度或肾小球滤过率变化之间无关联。
J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):e56-9. doi: 10.1097/QAI.0000000000000504.
2
ABCC2*1C and plasma tenofovir concentration are correlated to decreased glomerular filtration rate in patients receiving a tenofovir-containing antiretroviral regimen.ABCC2*1C和血浆替诺福韦浓度与接受含替诺福韦抗逆转录病毒治疗方案的患者肾小球滤过率降低相关。
J Antimicrob Chemother. 2014 Aug;69(8):2195-201. doi: 10.1093/jac/dku129. Epub 2014 Apr 30.
3
Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.接受替诺福韦治疗的HIV感染患者肾小管功能障碍的预测因素：一项药物遗传学研究。
Clin Infect Dis. 2009 Jun 1;48(11):e108-16. doi: 10.1086/598507.
4
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?较高的血浆维生素 D 结合蛋白和较低的游离骨化三醇水平与替诺福韦二吡呋酯的使用以及血浆和细胞内替诺福韦药代动力学相关：这是功能性维生素 D 缺乏的原因吗？
Antimicrob Agents Chemother. 2013 Nov;57(11):5619-28. doi: 10.1128/AAC.01096-13. Epub 2013 Sep 3.
5
[Conclusions. Tenofovir].[结论。替诺福韦]
Enferm Infecc Microbiol Clin. 2008 Jun;26 Suppl 8:62-4. doi: 10.1157/13126273.
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Unlikely association of multidrug-resistance protein 2 single-nucleotide polymorphisms with tenofovir-induced renal adverse events.
J Infect Dis. 2007 May 1;195(9):1389-90; author reply 1390-1. doi: 10.1086/513282.
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Tenofovir plasma concentrations in post-menopausal versus pre-menopausal HIV-infected women.
J Antimicrob Chemother. 2013 May;68(5):1206-7. doi: 10.1093/jac/dks519. Epub 2013 Jan 8.
8
Efficacy, safety and pharmacokinetics of tenofovir disoproxil fumarate in virologic-suppressed HIV-infected children using weight-band dosing.富马酸替诺福韦二吡呋酯在采用体重分组给药的病毒学抑制的HIV感染儿童中的疗效、安全性及药代动力学
Pediatr Infect Dis J. 2015 Apr;34(4):392-7. doi: 10.1097/INF.0000000000000633.
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Toward a pharmacogenetic understanding of nucleotide and nucleoside analogue toxicity.迈向对核苷酸和核苷类似物毒性的药物遗传学理解。
J Infect Dis. 2006 Dec 1;194(11):1471-4. doi: 10.1086/508550. Epub 2006 Oct 26.
10
Progression of renal impairment under therapy with tenofovir.
AIDS. 2005 Aug 12;19(12):1332-3. doi: 10.1097/01.aids.0000180109.03759.35.

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1
Effect of Pregnancy and Concomitant Antiretrovirals on the Pharmacokinetics of Tenofovir in Women With HIV Receiving Tenofovir Disoproxil Fumarate-Based Antiretroviral Therapy Versus Women With HBV Receiving Tenofovir Disoproxil Fumarate Monotherapy.妊娠和伴随抗逆转录病毒药物对接受富马酸替诺福韦二吡呋酯为基础的抗逆转录病毒治疗的 HIV 感染妇女与接受富马酸替诺福韦二吡呋酯单药治疗的 HBV 感染妇女中替诺福韦的药代动力学的影响。
J Clin Pharmacol. 2021 Mar;61(3):388-393. doi: 10.1002/jcph.1746. Epub 2020 Sep 22.
2
Plasma pharmacokinetics and urinary excretion of tenofovir following cessation in adults with controlled levels of adherence to tenofovir disoproxil fumarate.在对富马酸替诺福韦二吡呋酯具有良好依从性的成年人中停止治疗后，替诺福韦的血浆药代动力学和尿排泄。
Int J Infect Dis. 2020 Aug;97:365-370. doi: 10.1016/j.ijid.2020.06.037. Epub 2020 Jun 14.
3
Tenofovir Exposure during Pregnancy and Postpartum in Women Receiving Tenofovir Disoproxil Fumarate for the Prevention of Mother-to-Child Transmission of Hepatitis B Virus.替诺福韦酯在孕妇和产后妇女中的暴露情况，这些妇女正在接受替诺福韦二吡呋酯富马酸治疗以预防乙型肝炎病毒母婴传播。
Antimicrob Agents Chemother. 2018 Nov 26;62(12). doi: 10.1128/AAC.01686-18. Print 2018 Dec.
4
Drug Transporter Genetic Variants Are Not Associated with TDF-Related Renal Dysfunction in Patients with HIV-1 Infection: A Pharmacogenetic Study.药物转运体基因变异与HIV-1感染患者中替诺福韦酯相关的肾功能障碍无关：一项药物遗传学研究。
PLoS One. 2015 Nov 4;10(11):e0141931. doi: 10.1371/journal.pone.0141931. eCollection 2015.
5
Plasma and Intracellular Pharmacokinetics of Tenofovir Disoproxil Fumarate 300 mg Every 48 Hours vs 150 mg Once Daily in HIV-Infected Adults With Moderate Renal Function Impairment.每48小时服用300毫克富马酸替诺福韦二吡呋酯与每日一次服用150毫克富马酸替诺福韦二吡呋酯在中度肾功能损害的HIV感染成人中的血浆和细胞内药代动力学
Clin Infect Dis. 2015 Aug 15;61(4):633-9. doi: 10.1093/cid/civ346. Epub 2015 Apr 28.

本文引用的文献

1
Antiretrovirals and the kidney in current clinical practice: renal pharmacokinetics, alterations of renal function and renal toxicity.当前临床实践中的抗逆转录病毒药物与肾脏：肾脏药代动力学、肾功能改变及肾毒性
AIDS. 2014 Mar 13;28(5):621-32. doi: 10.1097/QAD.0000000000000103.
2
ABCC2*1C and plasma tenofovir concentration are correlated to decreased glomerular filtration rate in patients receiving a tenofovir-containing antiretroviral regimen.ABCC2*1C和血浆替诺福韦浓度与接受含替诺福韦抗逆转录病毒治疗方案的患者肾小球滤过率降低相关。
J Antimicrob Chemother. 2014 Aug;69(8):2195-201. doi: 10.1093/jac/dku129. Epub 2014 Apr 30.
3
Renal impairment in patients receiving a tenofovir-cART regimen: impact of tenofovir trough concentration.接受替诺福韦- cART 方案治疗的患者的肾功能损害：替诺福韦谷浓度的影响。
J Acquir Immune Defic Syndr. 2013 Apr 1;62(4):375-80. doi: 10.1097/QAI.0b013e31827ce4ee.
4
Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women.妊娠对替诺福韦药代动力学的影响：一项纳入 186 名女性的群体研究。
Antimicrob Agents Chemother. 2012 Feb;56(2):857-62. doi: 10.1128/AAC.05244-11. Epub 2011 Nov 28.
5
Impact of small body weight on tenofovir-associated renal dysfunction in HIV-infected patients: a retrospective cohort study of Japanese patients.体重较轻对 HIV 感染患者替诺福韦相关肾功能障碍的影响：日本患者的回顾性队列研究。
PLoS One. 2011;6(7):e22661. doi: 10.1371/journal.pone.0022661. Epub 2011 Jul 25.
6
Incidence and risk factors for tenofovir-associated renal function decline among Thai HIV-infected patients with low-body weight.泰国低体重HIV感染患者中替诺福韦相关肾功能下降的发生率及危险因素
Curr HIV Res. 2010 Oct;8(7):504-9. doi: 10.2174/157016210793499259.
7
Pharmacogenetics of tenofovir treatment.替诺福韦治疗的药物遗传学。
Pharmacogenomics. 2009 Oct;10(10):1675-85. doi: 10.2217/pgs.09.115.
8
Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.接受替诺福韦治疗的HIV感染患者肾小管功能障碍的预测因素：一项药物遗传学研究。
Clin Infect Dis. 2009 Jun 1;48(11):e108-16. doi: 10.1086/598507.
9
The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients.洛匹那韦/利托那韦对HIV感染患者中替诺福韦肾清除率的影响。
Clin Pharmacol Ther. 2008 Feb;83(2):265-72. doi: 10.1038/sj.clpt.6100269. Epub 2007 Jun 27.
10
Estimation of population pharmacokinetic parameters of saquinavir in HIV patients with the MONOLIX software.使用MONOLIX软件估算HIV患者中沙奎那韦的群体药代动力学参数。
J Pharmacokinet Pharmacodyn. 2007 Apr;34(2):229-49. doi: 10.1007/s10928-006-9043-z. Epub 2007 Jan 9.

No relationship between drug transporter genetic variants and tenofovir plasma concentrations or changes in glomerular filtration rate in HIV-infected adults.

作者信息

Sirirungsi Wasna, Urien Saik, Harrison Linda, Kamkon Jiraporn, Tawon Yardpiroon, Luekamlung Nuananong, Thongpaen Suchart, Nilmanat Ampaipith, Jourdain Gonzague, Lallemant Marc, Le Coeur Sophie, Ngo-Giang-Huong Nicole, Owen Andrew, Cressey Tim R

机构信息

*Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand †EAU08 University Paris Descartes and CIC1419 Inserm, Paris, France ‡Hopital Cochin, Assistance Publique-Hopitaux de Paris, Paris, France §Unite de Recherche clinique, AP-HP, Hopital Tarnier, Paris, France ‖Institut de Recherche pour le Développement (IRD) UMI 174-Program for HIV Prevention and Treatment (PHPT), Marseille, France ¶Lamphun Hospital, Lamphun, Thailand #Maha Sarakham Hospital, Maha Sarakham, Thailand **Hat Yai Hospital, Songkhla, Thailand ††Harvard School of Public Health, Boston, MA ‡‡Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

出版信息

J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):e56-9. doi: 10.1097/QAI.0000000000000504.

DOI:10.1097/QAI.0000000000000504
PMID:25559596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4334716/
Abstract
摘要