Yombi Jean C, Pozniak Anton, Boffito Marta, Jones Rachael, Khoo Saye, Levy Jeremy, Post Frank A
aAIDS Reference Centre, St Luc University Hospital, Catholic University of Louvain, Brussels, Belgium bSt Stephen's AIDS Trust, Chelsea and Westminster Hospital, London cUniversity of Liverpool, Liverpool dImperial College Healthcare NHS Trust eKing's College London School of Medicine, London, UK.
AIDS. 2014 Mar 13;28(5):621-32. doi: 10.1097/QAD.0000000000000103.
Assessment of renal function in HIV-positive patients is of increasing importance in the context of ageing and associated comorbidities. Exposure to nephrotoxic medications is widespread, and several commonly used antiretroviral drugs have nephrotoxic potential. Moreover, specific antiretrovirals inhibit renal tubular transporters resulting in the potential for drug-drug interactions as well as increases in serum creatinine concentrations, which affect estimates of glomerular filtration rate in the absence of changes in actual glomerular filtration rate. This review explores the effects of antiretroviral therapy on the kidney and offers an understanding of mechanisms that lead to apparent and real changes in renal function.
在艾滋病毒阳性患者老龄化及合并其他疾病的背景下，评估其肾功能变得越来越重要。接触具有肾毒性的药物十分普遍，几种常用的抗逆转录病毒药物都有潜在肾毒性。此外，特定的抗逆转录病毒药物会抑制肾小管转运蛋白，从而导致药物相互作用的可能性增加，以及血清肌酐浓度升高，这在实际肾小球滤过率未发生变化的情况下会影响肾小球滤过率的估算。本综述探讨了抗逆转录病毒疗法对肾脏的影响，并对导致肾功能出现明显和实际变化的机制进行了阐释。
