Department of Eating and Weight Disorders, Villa Garda Hospital, Via Montebaldo, 89, 37016 Garda, Verona, Italy.
Department of Neurological and Movement Sciences, University of Verona, Italy.
Clin Nutr. 2015 Dec;34(6):1224-32. doi: 10.1016/j.clnu.2014.12.012. Epub 2014 Dec 23.
BACKGROUND & AIMS: No study has yet compared body fat distribution before and after weight restoration in adolescent and adult patients with anorexia nervosa (AN) treated according to the same protocol. The study was set up to measure body fat distribution before and after short-term weight restoration in adolescent and adult patients with AN treated according to the same protocol in a specialist inpatient unit.
We recruited 33 consecutive adolescent female patients with AN, and 33 controls matched by age and post-treatment BMI centile, as well as 33 adult female patients with AN, and 33 controls matched by age and post-treatment BMI. Dual-energy X-ray absorptiometry (DXA) was used to assess body composition before and after short-term weight restoration (BMI ≥ 18.5 kg/m²).
Compared with controls, both adolescents and adults with AN showed that a greater amount of fat was lost from the extremities than the trunk before weight restoration, and that there was a central adiposity phenotype after short-term weight restoration. There were no significant differences in body fat distribution between adolescents and adults with AN before or after short-term weight restoration.
Adolescent and adult females with AN have similar body fat distribution both before and after short-term weight restoration, and show a central adiposity phenotype after short-term weight restoration. The clinical implications of this finding are as yet unknown. Clinical Trials Registry- Regional Fat Distribution in Adolescent Girls and Adults with Anorexia Nervosa (ISRCTN73572502).
目前尚无研究比较过采用相同方案治疗的青少年和成年神经性厌食症（AN）患者在体重恢复前后的体脂分布情况。本研究旨在测量采用相同方案在专科住院病房治疗的青少年和成年 AN 患者短期体重恢复前后的体脂分布。
我们招募了 33 名连续的患有 AN 的青少年女性患者，以及 33 名按年龄和治疗后 BMI 百分位匹配的对照者，还招募了 33 名患有 AN 的成年女性患者，以及 33 名按年龄和治疗后 BMI 百分位匹配的对照者。双能 X 线吸收法（DXA）用于评估短期体重恢复（BMI≥18.5kg/m²）前后的身体成分。
与对照组相比，AN 青少年和成年人在体重恢复前，四肢丢失的脂肪量比躯干多，且在短期体重恢复后出现中心性肥胖表型。青少年和成年 AN 患者在短期体重恢复前后的体脂分布无显著差异。
青少年和成年女性 AN 患者在短期体重恢复前后的体脂分布相似，且在短期体重恢复后出现中心性肥胖表型。这一发现的临床意义尚不清楚。临床试验注册-神经性厌食症青少年和成年女性的区域性脂肪分布（ISRCTN73572502）。
