State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian 116023, China.
Org Lett. 2015 Jan 16;17(2):190-3. doi: 10.1021/ol503118v. Epub 2015 Jan 5.
Highly enantioselective palladium-catalyzed formal hydrogenolysis of racemic N-sulfonyloxaziridines has been realized, providing a novel access to sultams with up to 99% ee. Preliminary mechanistic insights revealed that the reaction proceeded through a N-O bond cleavage, dehydration, and the sequential asymmetric hydrogenation.
手性钯催化的外消旋 N-磺酰氧恶唑烷的高对映选择性形式氢解已被实现，为带有高达 99%ee 的磺酰胺提供了一种新的途径。初步的机理研究表明，反应通过 N-O 键断裂、脱水和连续的不对称氢化进行。
