Sclafani Anthony, Ackroff Karen
Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA.
Chem Senses. 2015 Mar;40(3):181-6. doi: 10.1093/chemse/bju070. Epub 2015 Jan 5.
Advantame is a new ultrahigh-intensity noncaloric sweetener derived from aspartame and approved for human use. Rats and mice are not attracted to the taste of aspartame and this study determined their preference for advantame. In 24-h choice tests with water, C57BL/6J mice and Sprague-Dawley rats were indifferent to advantame at concentrations of 0.01, 0.03, and 0.1mM but significantly preferred 0.3 and 1mM advantame to water. Both species also preferred 1mM advantame to 1mM saccharin in direct choice tests, but preferred 10mM saccharin to 1mM advantame, which is near the solubility limit for this sweetener. Mice also preferred 1mM advantame to 1mM sucralose or acesulfame K, but preferred both sweeteners at 10mM to 1mM advantame. In addition, mice preferred 1mM advantame to 1 and 10mM aspartame. Thus, advantame is a potent sweetener for rodents but, because of limited solubility, is not an effective alternative to saccharin, sucralose, or acesulfame K at higher concentrations.
阿凡塔甜是一种新型的超高强度无热量甜味剂，由阿斯巴甜衍生而来，已被批准用于人类。大鼠和小鼠对阿斯巴甜的味道不感兴趣，本研究确定了它们对阿凡塔甜的偏好。在用水进行的24小时选择试验中，C57BL/6J小鼠和斯普拉格-道利大鼠对浓度为0.01、0.03和0.1mM的阿凡塔甜无偏好，但明显更喜欢0.3和1mM的阿凡塔甜而不是水。在直接选择试验中，这两个物种也更喜欢1mM的阿凡塔甜而不是1mM的糖精，但更喜欢10mM的糖精而不是1mM的阿凡塔甜，这接近这种甜味剂的溶解度极限。小鼠也更喜欢1mM的阿凡塔甜而不是1mM的三氯蔗糖或安赛蜜钾，但更喜欢10mM的这两种甜味剂而不是1mM的阿凡塔甜。此外，小鼠更喜欢1mM的阿凡塔甜而不是1和10mM的阿斯巴甜。因此，阿凡塔甜对啮齿动物来说是一种强效甜味剂，但由于溶解度有限，在较高浓度下它不是糖精、三氯蔗糖或安赛蜜钾的有效替代品。
