Chen Huaiqiong, Guan Yongguang, Zhong Qixin
Department of Food Science and Technology, University of Tennessee , 2510 River Drive, Knoxville, Tennessee 37996, United States.
J Agric Food Chem. 2015 Jan 28;63(3):983-9. doi: 10.1021/jf504146t. Epub 2015 Jan 13.
The objectives of the present study were to improve the capability of microemulsions to dissolve peppermint oil by blending sunflower lecithin with Tween 20 and to study the possibility of codelivering lipophilic bioactive compounds. The oil loading in microemulsions with 20% (w/w) Tween 20 increased from 3% (w/w) to 20% (w/w) upon gradual supplementation of 6% (w/w) lecithin. All microemulsions had particles of <12 nm that did not change over 70 d of storage at 21 °C. They had relatively low Newtonian viscosities and were physically and chemically stable after 50-200-fold dilution in water, resulting from similar hydrophile-lipophile-balance values of the surfactant mixture and peppermint oil. Furthermore, the microemulsions were capable of dissolving coenzyme Q10 and preventing its degradation at UV 302 nm, more significant for the microemulsion with lecithin. Therefore, natural surfactant lecithin can reduce the use of synthetic Tween 20 to dissolve peppermint oil and protect the degradation of dissolved lipophilic bioactive components in transparent products.
本研究的目的是通过将向日葵卵磷脂与吐温20混合来提高微乳液溶解薄荷油的能力，并研究共递送亲脂性生物活性化合物的可能性。随着6%（w/w）卵磷脂的逐渐添加，含20%（w/w）吐温20的微乳液中的油负载量从3%（w/w）增加到20%（w/w）。所有微乳液的颗粒均小于12 nm，在21°C下储存70天内没有变化。它们具有相对较低的牛顿粘度，在水中稀释50 - 200倍后物理和化学性质稳定，这是由于表面活性剂混合物和薄荷油的亲水亲油平衡值相似。此外，微乳液能够溶解辅酶Q10并防止其在302 nm紫外线下降解，对于含卵磷脂的微乳液来说这种作用更显著。因此，天然表面活性剂卵磷脂可以减少合成吐温20的用量来溶解薄荷油，并保护透明产品中溶解的亲脂性生物活性成分不被降解。
