葡萄糖转运蛋白12（GLUT12）会是癌症治疗中的潜在治疗靶点吗？一份初步报告。
Could GLUT12 be a Potential Therapeutic Target in Cancer Treatment? A Preliminary Report.
作者信息
Pujol-Gimenez Jonai, de Heredia Fátima Pérez, Idoate Miguel Angel, Airley Rachel, Lostao María Pilar, Evans Andrew Robert
机构信息
1. Department of Nutrition, Food Science and Physiology, School of Pharmacy, University of Navarra, Pamplona, Spain.
2. School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, UK.
出版信息
J Cancer. 2015 Jan 5;6(2):139-43. doi: 10.7150/jca.10429. eCollection 2015.
BACKGROUND
Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells.
METHODS
GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model.
RESULTS
GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism.
CONCLUSION
The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.
背景
最近的研究表明，GLUT12是参与癌细胞糖酵解代谢的主要葡萄糖转运蛋白。
方法
通过免疫组织化学法在一系列癌细胞系和肿瘤球体模型中测定GLUT12的表达。
结果
GLUT12在A549和RH-36中高表达；在HT29中低表达；在NB-EB癌细胞系中不表达。GLUT12表达位于以无氧代谢为特征的HT29球体的坏死中心。
结论
这些数据支持GLUT12参与癌细胞的糖酵解代谢，因此，其作为癌症治疗新靶点的潜力。
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