Zafrani B, Vielh P, Fourquet A, Mosseri V, Durand J C, Salmon R J, Vilcoq J R
Department of Pathology, Institut Curie, Paris, France.
Eur J Cancer Clin Oncol. 1989 Nov;25(11):1645-50. doi: 10.1016/0277-5379(89)90311-8.
Four hundred and thirty-four patients with infiltrative ductal carcinoma were treated by limited surgery and irradiation between January 1960 and December 1980. The median follow-up was 103 months. Retrospective pathological analysis of the primary tumor identified a subset of pathological parameters which were predictors of local breast failure and survival. Pathological predictors of local breast recurrence were: incomplete surgical excision (P less than 0.0001), lymphatic invasion (P less than 0.02) and presence of an extensive in situ component (EDISC) (P less than 0.03). Pathological predictors of survival were: incomplete surgery (P less than 0.007), size of the primary tumour (P less than 0.03), high histologic grade (P less than 0.005), lymphatic invasion (P less than 0.0001) and absence of associated in situ component (P less than 0.008). This study emphasizes the role of the in situ component in the prognosis of breast carcinoma treated with conservative management.
1960年1月至1980年12月期间，434例浸润性导管癌患者接受了局部手术和放疗。中位随访时间为103个月。对原发肿瘤进行回顾性病理分析，确定了一组病理参数，这些参数是局部乳腺失败和生存的预测指标。局部乳腺复发的病理预测指标为：手术切除不完整（P<0.0001）、淋巴管侵犯（P<0.02）和广泛原位成分（EDISC）的存在（P<0.03）。生存的病理预测指标为：手术不完整（P<0.007）、原发肿瘤大小（P<0.03）、高组织学分级（P<0.005）、淋巴管侵犯（P<0.0001）和无相关原位成分（P<0.008）。本研究强调了原位成分在保守治疗乳腺癌预后中的作用。
