Bartelink H, Borger J H, van Dongen J A, Peterse J L
Department of Radiotherapy, The Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), Amsterdam.
Radiother Oncol. 1988 Apr;11(4):297-303. doi: 10.1016/0167-8140(88)90200-9.
To investigate possible contraindications for breast-conserving therapy (BCT) a retrospective clinicopathological study was carried out in 585 patients treated conservatively in The Netherlands Cancer Institute from 1979 to 1984. The local recurrence rate in the breast was 2% at 6 years and was similar in stages I and II breast cancer. Invasive cancer with extensive ductal carcinoma in situ (DCIS) component appeared to be the only main prognostic factor when local failure in the breast was considered. A multivariate analysis revealed that tumor size, microscopically incomplete excision of the primary tumor and age did not have a significant influence on local control alone, when this was corrected for extensive DCIS. When breast and axillary recurrences were taken together, age and extensive DCIS component appeared to be two independent prognostic factors according to a multivariate analysis. Especially patients younger than 40 years with an extensive DCIS component had a higher locoregional recurrence rate.
为了研究保乳治疗（BCT）的可能禁忌证，我们对1979年至1984年在荷兰癌症研究所接受保守治疗的585例患者进行了一项回顾性临床病理研究。6年时乳腺局部复发率为2%，I期和II期乳腺癌相似。当考虑乳腺局部失败时，伴有广泛导管原位癌（DCIS）成分的浸润性癌似乎是唯一的主要预后因素。多变量分析显示，在对广泛DCIS进行校正后，肿瘤大小、原发肿瘤镜下切除不完全以及年龄单独对局部控制没有显著影响。根据多变量分析，当将乳腺和腋窝复发合并考虑时，年龄和广泛DCIS成分似乎是两个独立的预后因素。尤其是年龄小于40岁且伴有广泛DCIS成分的患者，其局部区域复发率更高。
