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从成年大鼠脑中分离出的经γ干扰素处理的小胶质细胞，其Fc受体密度、MHC抗原表达及超氧化物生成均增加。

Fc receptor density, MHC antigen expression and superoxide production are increased in interferon-gamma-treated microglia isolated from adult rat brain.

作者信息

Woodroofe M N, Hayes G M, Cuzner M L

机构信息

Department of Neurochemistry, Institute of Neurology, London, U.K.

出版信息

Immunology. 1989 Nov;68(3):421-6.

PMID:2556346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1385458/
Abstract

Treatment of microglia isolated from adult rat brain with interferon-gamma (IFN-gamma) at a concentration of 1 U/ml resulted in enhanced expression of Fc receptors and major histocompatibility complex (MHC) antigens and increased production of superoxide anions. Neonatal microglia and peritoneal macrophages, isolated and cultured in the same manner, displayed functional properties very similar to those of adult microglia, indicating a common origin for different macrophage populations. The Fc binding capacity of microglia was found to be significantly greater than that of peritoneal cells, thus underlining the potential role of microglia in immune-mediated demyelination.

摘要

用浓度为1 U/ml的γ-干扰素（IFN-γ）处理从成年大鼠脑中分离出的小胶质细胞，会导致Fc受体和主要组织相容性复合体（MHC）抗原的表达增强，以及超氧阴离子的产生增加。以相同方式分离和培养的新生小胶质细胞和腹腔巨噬细胞，表现出与成年小胶质细胞非常相似的功能特性，这表明不同巨噬细胞群体有共同的起源。发现小胶质细胞的Fc结合能力明显大于腹腔细胞，从而突出了小胶质细胞在免疫介导的脱髓鞘中的潜在作用。

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本文引用的文献

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Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques.进行性多发性硬化斑块中髓鞘的持续分解和再生。
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