Hayes G M, Woodroofe M N, Cuzner M L
J Neurol Sci. 1987 Aug;80(1):25-37. doi: 10.1016/0022-510x(87)90218-8.
In normal human white matter the predominant cell type expressing MHC Class II is the microglia. This population of cells reacts with the pan macrophage marker, EBM/11, and constitutes about 13% of the glial cell population. The intensity of staining was enhanced and the absolute number of Class II+ microglia increased in normal appearing white matter from multiple sclerosis (MS) brain. As T cell activation in MS may occur in the brain the upregulation of microglia bearing MHC Class II may reflect their function as antigen presenting cells in the development of inflammatory lesions.
在正常人类白质中，表达MHC II类分子的主要细胞类型是小胶质细胞。这群细胞与泛巨噬细胞标志物EBM/11发生反应，约占神经胶质细胞群体的13%。在多发性硬化症（MS）患者大脑中外观正常的白质中，II类小胶质细胞的染色强度增强，其绝对数量增加。由于MS中的T细胞活化可能发生在大脑中，携带MHC II类分子的小胶质细胞上调可能反映了它们在炎症性病变发展过程中作为抗原呈递细胞的功能。
