低剂量利比角闪石石棉暴露的高分辨率计算机断层扫描/计算机断层扫描及相关肺量计效应

HRCT/CT and associated spirometric effects of low Libby amphibole asbestos exposure.

作者信息

Lockey James E, Dunning Kari, Hilbert Timothy J, Borton Eric, Levin Linda, Rice Carol H, McKay Roy T, Shipley Ralph, Meyer Cristopher A, Perme Charles, LeMasters Grace K

机构信息

From the Department of Environmental Health, Pulmonary Medicine, Department of Internal Medicine (Dr Lockey), Department of Rehabilitation Sciences (Dr Dunning), and Department of Environmental Health (Mr Hilbert, Mr Borton, Drs Levin, Rice, and LeMasters), University of Cincinnati; Occupational Pulmonary Services (Dr McKay) and Department of Radiology (Dr Shipley), University of Cincinnati College of Medicine, Ohio; Department of Radiology, University of Wisconsin School of Medicine and Public Health (Dr Meyer), Madison; and Department of Radiology, Mercy Health-Anderson Hospital Cincinnati (Dr Perme), Ohio.

出版信息

J Occup Environ Med. 2015 Jan;57(1):6-13. doi: 10.1097/JOM.0000000000000373.

DOI:10.1097/JOM.0000000000000373

PMID:25563535

Abstract

OBJECTIVE

Evaluate the relationship between cumulative fiber exposure and high-resolution or conventional chest computed tomography (HRCT/CT) changes and spirometry of workers with Libby amphibole asbestos exposure.

METHODS

Of the original 1980 cohort (n = 513), 431 were living and asked to participate. Images were evaluated for localized pleural thickening (LPT), diffuse pleural thickening (DPT), and parenchymal changes.

RESULTS

A total of 306 participants provided either HRCT/CT scans (n = 191) or chest radiographs (n = 115). Of the 191 with HRCT/CT, 52.9% had pleural changes and 13.1% had parenchymal changes. Those with LPT only, LPT and/or DPT, or DPT and/or parenchymal changes had mean 6.1, 8.0, and 18.0 loss in percent predicted forced vital capacity, respectively.

CONCLUSIONS

Exposure to vermiculite containing amphibole fibers is associated with pleural and parenchymal HRCT/CT changes at low cumulative fiber exposure; these changes are associated with spirometric decrements.

摘要

目的

评估接触利比角闪石石棉的工人的累积纤维暴露量与高分辨率或传统胸部计算机断层扫描（HRCT/CT）变化及肺功能测定之间的关系。

方法

在最初的1980名队列研究对象（n = 513）中，431名在世且被邀请参与研究。对影像进行局部胸膜增厚（LPT）、弥漫性胸膜增厚（DPT）和实质改变的评估。

结果

共有306名参与者提供了HRCT/CT扫描结果（n = 191）或胸部X光片（n = 115）。在191名进行HRCT/CT检查的参与者中，52.9%有胸膜改变，13.1%有实质改变。仅患有LPT、患有LPT和/或DPT、或患有DPT和/或实质改变的参与者，其预计用力肺活量百分比平均分别下降6.1%、8.0%和18.0%。