Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia 30341, USA.
J Occup Environ Med. 2012 Jan;54(1):56-63. doi: 10.1097/JOM.0b013e31823c141c.
To examine the association between cumulative fiber exposure and health outcomes in workers (n = 336) with Libby amphibole exposure.
Exposure-response relationships were explored by the use of logistic regression, with cumulative fiber exposure modeled in categories and as a continuous variable.
The use of spline functions with lifetime cumulative fiber exposure as a continuous variable showed that the odds of localized pleural thickening were significantly elevated at less than 1 f/cc-y. Odds of parenchymal abnormalities, restrictive spirometry, and chronic bronchitis were also significantly elevated at 108, 166, and 24 f/cc-y, respectively.
The odds of several pulmonary health outcomes are correlated with cumulative exposure to Libby amphibole. That relatively low-lifetime cumulative exposures are associated with localized pleural thickening has implications for the non-cancer-risk assessment for Libby amphibole.
研究累积纤维暴露与利比角闪石暴露工人（n=336）健康结果之间的关联。
采用逻辑回归方法探讨暴露反应关系，以分类和连续变量的形式对累积纤维暴露进行建模。
使用样条函数对终生累积纤维暴露进行连续变量建模，结果表明，局部胸膜增厚的几率在小于 1 f/cc-y 时显著升高。实质异常、限制性肺通气功能障碍和慢性支气管炎的几率分别在 108、166 和 24 f/cc-y 时显著升高。
累积暴露于利比角闪石与几种肺部健康结果的几率相关。相对较低的终生累积暴露与局部胸膜增厚有关，这对利比角闪石的非癌症风险评估具有重要意义。
