芬兰炼油行业中的肾癌风险：一项巢式病例对照研究。
Kidney cancer risk in oil refining in Finland: a nested case-referent study.
作者信息
Anttila Ahti, Pokhrel Arun, Heikkilä Pirjo, Viinanen Riitta, Pukkala Eero
机构信息
From the Finnish Cancer Registry (Drs Anttila, Pokhrel, and Pukkala), Institute for Statistical and Epidemiological Cancer Research, Unioninkatu 22; Finnish Institute of Occupational Health (Dr Heikkilä), Topeliuksenkatu 41aA, Helsinki; RV Chem Oy (Mr Viinanen), Ruoriniemenkatu 12, Lahti; and School of Health Sciences (Dr Pukkala), University of Tampere, Finland.
出版信息
J Occup Environ Med. 2015 Jan;57(1):68-72. doi: 10.1097/JOM.0000000000000301.
OBJECTIVE
The purpose of this study was to assess whether occupational exposure to hydrocarbons in the oil-refining activity increases the risk of kidney cancer.
METHODS
This case-referent study was nested within the cohort of employees in the oil refinery industry in Finland in 1967 to 1982 (n = 9454). The final data included 30 cases of kidney cancer and 81 age- and sex-matched referents.
RESULTS
There was a threefold increase in the kidney cancer risk for exposure to hydrocarbons in crude oil (odds ratio, 3.1; confidence interval, 1.1 to 8.9; 11 exposed cases). The risk was associated with the highest cumulative exposure category to hydrocarbons in crude oil.
CONCLUSIONS
Occupational exposure in oil refining, particularly to crude oil, may increase kidney cancer risk. The study assessed historical exposures; further information needs to be collected for evaluating current exposures.
目的
本研究旨在评估炼油活动中的职业性碳氢化合物暴露是否会增加患肾癌的风险。
方法
本病例对照研究嵌套于1967年至1982年芬兰炼油行业员工队列中（n = 9454）。最终数据包括30例肾癌病例和81例年龄及性别匹配的对照。
结果
原油碳氢化合物暴露使患肾癌风险增加了两倍（比值比，3.1；置信区间，1.1至8.9；11例暴露病例）。该风险与原油碳氢化合物的最高累积暴露类别相关。
结论
炼油过程中的职业暴露，尤其是原油暴露，可能会增加患肾癌的风险。本研究评估的是历史暴露情况；需要收集更多信息以评估当前暴露情况。
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