25000名男性海上石油工人按解剖部位划分的芳香烃与皮肤癌风险
Aromatic hydrocarbons and risk of skin cancer by anatomical site in 25 000 male offshore petroleum workers.
作者信息
Stenehjem Jo Steinson, Robsahm Trude Eid, Bråtveit Magne, Samuelsen Sven Ove, Kirkeleit Jorunn, Grimsrud Tom Kristian
机构信息
Department of Research, Cancer Registry of Norway, Oslo, Norway.
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
出版信息
Am J Ind Med. 2017 Aug;60(8):679-688. doi: 10.1002/ajim.22741.
BACKGROUND
We prospectively examined skin cancer risk according to occupational exposure to aromatic hydrocarbons with adjustment for ultraviolet radiation exposure, in a cohort of 24 917 male offshore petroleum workers.
METHODS
Hazard ratios (HRs) and 95% confidence intervals were estimated with Cox regression adapted to a stratified case-cohort design.
RESULTS
During 13.5 years of follow-up, 112 cutaneous melanomas (CMs) and 70 non-melanoma skin cancers were identified. Increased risks of CM and of squamous cell carcinoma on the forearm and hand were seen among those ever exposed to crude oil or benzene. For skin cancers of the forearm and hand combined, cumulative and duration metrics of benzene exposure showed P of 0.031 and 0.003, respectively.
CONCLUSIONS
Our results support an association between exposure to crude oil or benzene and skin cancer risk on hands and forearms among offshore petroleum workers. Dermal uptake of polycyclic aromatic hydrocarbons or benzene may explain this association.
背景
在一个由24917名男性海上石油工人组成的队列中，我们前瞻性地研究了根据职业性接触芳香烃并调整紫外线辐射暴露情况后的皮肤癌风险。
方法
采用适用于分层病例队列设计的Cox回归估计风险比（HRs）和95%置信区间。
结果
在13.5年的随访期间，共确诊112例皮肤黑色素瘤（CMs）和70例非黑色素瘤皮肤癌。在曾经接触过原油或苯的人群中，前臂和手部的CM以及鳞状细胞癌风险增加。对于前臂和手部合并的皮肤癌，苯暴露的累积量和暴露持续时间指标的P值分别为0.031和0.003。
结论
我们的结果支持海上石油工人接触原油或苯与手部和前臂皮肤癌风险之间存在关联。多环芳烃或苯的皮肤吸收可能解释了这种关联。
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