Gerbaud P, Pidoux G
INSERM, U1139, Paris F-75006, France; Université Paris Descartes, Paris F-75006, France.
INSERM, U1139, Paris F-75006, France; Université Paris Descartes, Paris F-75006, France.
Placenta. 2015 Apr;36 Suppl 1:S35-42. doi: 10.1016/j.placenta.2014.12.015. Epub 2014 Dec 24.
During human placentation, mononuclear cytotrophoblasts fuse to form a multinucleated syncytia ensuring hormonal production and nutrient exchanges between the maternal and fetal circulation. Syncytia formation is essential for the maintenance of pregnancy and for fetal growth. The trophoblast cell fusion process first requires the acquisition of cell fusion properties, then cells set up plasma membrane protein macrocomplexes and fusogen machinery that trigger cell-cell fusion. Numerous proteins have been shown to be directly involved in the initiation of trophoblast cell fusion. These proteins must expressed at the right time and in the right place to trigger cell-cell fusion. In this review, we describe the role of certain fusogenic protein macrocomplexes that form the scaffold for the fusogen machinery underlying human trophoblastic-lipid mixing and merging of cell contents that lead to cell fusion in physiological conditions.
在人类胎盘形成过程中，单核细胞滋养层细胞融合形成多核合体，确保母胎循环之间的激素产生和营养物质交换。合体形成对于维持妊娠和胎儿生长至关重要。滋养层细胞融合过程首先需要获得细胞融合特性，然后细胞建立触发细胞间融合的质膜蛋白大复合体和融合原机制。许多蛋白质已被证明直接参与滋养层细胞融合的起始。这些蛋白质必须在正确的时间和位置表达，以触发细胞间融合。在本综述中，我们描述了某些融合蛋白大复合体的作用，这些复合体构成了在生理条件下导致细胞融合的人类滋养层脂质混合和细胞内容物合并的融合原机制的支架。
