通过三唑-金和胺催化接力实现二烯醛的环境合成。
Ambient synthesis of dienals via triazole-gold and amine catalysis relay.
作者信息
Motika Stephen E, Wang Qiaoyi, Ye Xiaohan, Shi Xiaodong
机构信息
C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26506, United States.
出版信息
Org Lett. 2015 Jan 16;17(2):290-3. doi: 10.1021/ol503393a. Epub 2015 Jan 7.
PMID:25564703
Abstract
A highly efficient synthesis of substituted conjugated dienals was developed through a triazole-gold (TA-Au)-catalyzed propargyl vinyl ether rearrangement followed by an amine catalyzed allene-aldehyde tautomerization. Various substituted vinylogous aldehydes were prepared in one pot with good to excellent yields (up to 95%) under mild conditions with high atom economy.
摘要
通过三唑-金（TA-Au）催化的炔丙基乙烯基醚重排，随后胺催化的丙二烯-醛互变异构化，开发了一种高效合成取代共轭二烯醛的方法。在温和条件下，以高原子经济性，通过一锅法制备了各种取代的烯醇式醛，产率良好至优异（高达95%）。
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