氧化磷酸化在癌症进展中的重要作用。
Essential role for oxidative phosphorylation in cancer progression.
机构信息
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France.
Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Université Pierre et Marie Curie, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
出版信息
Cell Metab. 2015 Jan 6;21(1):11-2. doi: 10.1016/j.cmet.2014.12.013.
Cancers are often affected by derangements in mitochondrial (mt) function, as well as mtDNA mutations. In this issue, Tan et al. (2015) demonstrate that only mtDNA-depleted cancer cells capable of recovering mtDNA from the host form metastasizing cancers in vivo, revealing an essential requirement for oxidative phosphorylation in tumor progression.
癌症通常受到线粒体 (mt) 功能障碍以及 mtDNA 突变的影响。在本期杂志中，Tan 等人（2015 年）表明，只有能够从宿主中恢复 mtDNA 的 mtDNA 耗竭的癌细胞才能在体内形成转移性癌症，这揭示了氧化磷酸化在肿瘤进展中的重要需求。
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