Kapoor Deepak N, Bhatia Amit, Kaur Ripandeep, Sharma Ruchi, Kaur Gurvinder, Dhawan Sanju
School of Pharmaceutical Sciences (LSPS), Faculty of Applied Medical Sciences (LFAMS), Lovely Professional University (LPU), Phagwara, Punjab, India.
Ther Deliv. 2015 Jan;6(1):41-58. doi: 10.4155/tde.14.91.
Biodegradable polymers have played an important role in the delivery of drugs in a controlled and targeted manner. Polylactic-co-glycolic acid (PLGA) is one of the extensively researched synthetic biodegradable polymers due to its favorable properties. It is also known as a 'Smart Polymer' due to its stimuli sensitive behavior. A wide range of PLGA-based drug delivery systems have been reported for the treatment or diagnosis of various diseases and disorders. The present review provides an overview of the chemistry, physicochemical properties, biodegradation behavior, evaluation parameters and applications of PLGA in drug delivery. Different drug-polymer combinations developed into drug delivery or carrier systems are enumerated and discussed.
可生物降解聚合物在药物的控释和靶向递送中发挥了重要作用。聚乳酸-乙醇酸共聚物（PLGA）因其良好的性能，是研究广泛的合成可生物降解聚合物之一。由于其对刺激的敏感行为，它也被称为“智能聚合物”。已经报道了多种基于PLGA的药物递送系统用于治疗或诊断各种疾病和病症。本综述概述了PLGA在药物递送中的化学性质、物理化学性质、生物降解行为、评价参数及应用。列举并讨论了开发成药物递送或载体系统的不同药物-聚合物组合。
