Urbina Olatz, Ferrández Olivia, Luque Sònia, Grau Santiago, Mojal Sergi, Pellicer Rosa, Riu Marta, Salas Esther, Comin-Colet Josep
Pharmacy Department, Hospital Universitari del Mar, Barcelona, Spain.
Pharmacy Department, Hospital Universitari del Mar, Barcelona, Spain ; Universitat Autònoma de Barcelona, Barcelona, Spain.
Ther Clin Risk Manag. 2014 Dec 17;11:9-15. doi: 10.2147/TCRM.S71749. eCollection 2015.
Because of the high incidence of drug-related problems (DRPs) among hospitalized patients with cardiovascular diseases and their potential impact on morbidity and mortality, it is important to identify the most susceptible patients, who therefore require closer monitoring of drug therapy.
To identify the profile of patients at higher risk of developing at least one DRP during hospitalization in a cardiology ward.
We consecutively included all patients hospitalized in the cardiology ward of a teaching hospital in 2009. DRPs were identified through a computerized warning system designed by the pharmacy department and integrated into the electronic medical record.
A total of 964 admissions were included, and at least one DRP was detected in 29.8%. The variables associated with a higher risk of these events were polypharmacy (odds ratio [OR]=1.228; 95% confidence interval [CI]=1.153-1.308), female sex (OR=1.496; 95% CI=1.026-2.180), and first admission (OR=1.494; 95% CI=1.005-2.221).
Monitoring patients through a computerized warning system allowed the detection of at least one DRP in one-third of the patients. Knowledge of the risk factors for developing these problems in patients admitted to hospital for cardiovascular problems helps in identifying the most susceptible patients.
由于心血管疾病住院患者中药物相关问题（DRP）的发生率较高，且这些问题对发病率和死亡率有潜在影响，因此识别最易受影响的患者很重要，这些患者需要更密切地监测药物治疗。
确定在心脏病病房住院期间发生至少一种DRP风险较高的患者特征。
我们连续纳入了2009年在一家教学医院心脏病病房住院的所有患者。通过药房设计并整合到电子病历中的计算机化预警系统识别DRP。
共纳入964例住院患者，其中29.8%检测到至少一种DRP。与这些事件风险较高相关的变量包括用药种类多（比值比[OR]=1.228；95%置信区间[CI]=1.153 - 1.308）、女性（OR=1.496；95% CI=1.026 - 2.180）和首次住院（OR=1.494；95% CI=1.005 - 2.221）。
通过计算机化预警系统对患者进行监测，可在三分之一的患者中检测到至少一种DRP。了解心血管疾病住院患者发生这些问题的风险因素有助于识别最易受影响的患者。
