Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Department of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
PLoS One. 2020 Aug 28;15(8):e0237781. doi: 10.1371/journal.pone.0237781. eCollection 2020.
Drug therapy problems (DTPs) are major concerns of healthcare and have been identified to contribute to negative clinical outcomes. The occurrence of DTPs in heart failure patients is associated with worsening of outcomes. The aim of this study was to assess DTPs, associated factors and patient satisfaction among ambulatory heart failure patients at Tikur Anbessa Specialized Hospital (TASH).
A hospital based prospective cross-sectional study was conducted on 423 heart failure patients on follow up at TASH. Data was collected through patient interview and chart review. Descriptive statistics, binary and multiple logistic regressions were used for analyses and P < 0.05 was used to declare association.
Majority of the patients were in NYHA class III (55.6%) and 66% of them had preserved systolic function. DTPs were identified in 291(68.8%) patients, with an average number of 2.51±1.07.per patient. The most common DTPs were drug interaction (27.3%) followed by noncompliance (26.2%), and ineffective drug use (13.7%). β blockers were the most frequent drug class involved in DTPs followed by angiotensin converting enzyme inhibitors. The global satisfaction was 78% and the overall mean score of treatment satisfaction was 60.5% (SD, 10.5).
Prevalence of DTPs as well as non-adherence among heart failure patients on follow up is relatively high. Detection and prevention of DTPs along with identifying patients at risk can save lives, help to adopt efficient strategies to closely monitor patients at risk, enhance patient's quality of life and optimize healthcare costs.
药物治疗问题（DTPs）是医疗保健的主要关注点，并已被确定会导致负面的临床结果。心力衰竭患者发生 DTPs 与结局恶化有关。本研究旨在评估提格雷安巴塞专科医院（TASH）门诊心力衰竭患者的 DTPs、相关因素和患者满意度。
在 TASH 接受随访的 423 例心力衰竭患者中进行了一项基于医院的前瞻性横断面研究。通过患者访谈和病历回顾收集数据。采用描述性统计、二项和多项逻辑回归进行分析，P<0.05 表示关联。
大多数患者处于 NYHA 分级 III 级（55.6%），其中 66%的患者有收缩功能保留。在 291 名（68.8%）患者中发现了 DTPs，平均每名患者有 2.51±1.07 个 DTPs。最常见的 DTPs 是药物相互作用（27.3%），其次是不遵医嘱（26.2%）和药物使用无效（13.7%）。β受体阻滞剂是最常见的涉及 DTPs 的药物类别，其次是血管紧张素转换酶抑制剂。总体满意度为 78%，治疗满意度的总体平均得分为 60.5%（SD，10.5）。
随访心力衰竭患者的 DTPs 发生率以及不遵医嘱的情况相对较高。检测和预防 DTPs 以及识别有风险的患者可以挽救生命，有助于采取有效的策略密切监测有风险的患者，提高患者的生活质量并优化医疗保健成本。
