Sequerra Eduardo B
Instituto do Cérebro, Universidade Federal do Rio Grande do Norte Natal, RN, Brazil.
Front Cell Neurosci. 2014 Dec 22;8:434. doi: 10.3389/fncel.2014.00434. eCollection 2014.
The adult mammalian brain harbors a population of cells around their lateral ventricles capable of giving rise to new neurons throughout life. The so-called subventricular zone (SVZ) is a heterogeneous germinative niche in regard to the neuronal types it generates. SVZ progenitors give rise to different olfactory bulb (OB) interneuron types in accordance to their position along the ventricles. Here, I review data showing the difference between progenitors located along different parts of the SVZ axes and ages. I also discuss possible mechanisms for the origin of this diversity.
成年哺乳动物的大脑在其侧脑室周围存在一群细胞，这些细胞在整个生命过程中都能够产生新的神经元。所谓的脑室下区（SVZ）就其产生的神经元类型而言，是一个异质性的生发微环境。SVZ祖细胞根据其沿脑室的位置产生不同类型的嗅球（OB）中间神经元。在这里，我回顾了显示沿SVZ轴不同部位和不同年龄的祖细胞之间差异的数据。我还讨论了这种多样性起源的可能机制。
