Lin Bao-Qin, Zhong Chun-Mei, Lin Jun-Li, Hu Lu-Yun, Chen Wen-Pei, Zhang Zi-Yang
Guangzhou University of Chinese Medicine, China.
Zhong Yao Cai. 2014 Jul;37(7):1218-21.
To investigate effects of Danhong Huayu Koufuye (DHK), insulin and their combination on diabetic cardiomyopathy (DC) in streptozotocin (STZ, 50 mg/kg, ip)-induced diabetic rats.
Rats were divided into five groups: normal control, diabetic treated with vehicle, insulin, DHK, and DHK plus insulin. The animals were treated once daily for 15 weeks starting one week after STZ injection.
The combination of DHK with insulin significantly reduced cardiac index (P < 0.05), serum LDH (P < 0.05), AST(P < 0.05), ALT(P < 0.05) and HDL-C (P < 0.05) level, and promoted pancreatic and cardiac morphological changes as compared with the model group.
It is suggested that DHK may be a valuable adjuvant therapy for DC.
研究丹红化瘀口服液（DHK）、胰岛素及其联合应用对链脲佐菌素（STZ，50mg/kg，腹腔注射）诱导的糖尿病大鼠糖尿病性心肌病（DC）的影响。
将大鼠分为五组：正常对照组、溶剂治疗糖尿病组、胰岛素治疗组、DHK治疗组和DHK加胰岛素治疗组。自注射STZ一周后开始，动物每天接受一次治疗，持续15周。
与模型组相比，DHK与胰岛素联合应用显著降低了心脏指数（P<0.05）、血清乳酸脱氢酶（LDH）（P<0.05）、天冬氨酸转氨酶（AST）（P<0.05）、丙氨酸转氨酶（ALT）（P<0.05）水平及高密度脂蛋白胆固醇（HDL-C）（P<0.05）水平，并促进了胰腺和心脏的形态学改变。
提示DHK可能是DC一种有价值的辅助治疗药物。
