Thind R, O'Neill D W, Del Regno A, Notman R
Department of Chemistry and Centre for Scientific Computing, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.
Chem Commun (Camb). 2015 Mar 28;51(25):5406-9. doi: 10.1039/c4cc08527b.
We show that ethanol can induce the formation of water-permeable defects in model membranes of skin, providing a fresh perspective on ethanol as a membrane modulator. We rationalise our findings in terms of the chemical nature of ethanol, i.e., a combination of its hydrogen bonding propensity and amphiphilic character.
我们发现乙醇能够在皮肤模型膜中诱导形成水可渗透的缺陷，这为乙醇作为一种膜调节剂提供了全新的视角。我们从乙醇的化学性质，即其氢键形成倾向和两亲性的结合，来解释我们的发现。
