Everything Skin & Hair, Medical & Aesthetic Dermatology Clinic, Mumbai, India.
Marico R&D Center, Marico Limited, Mumbai, India.
J Cosmet Dermatol. 2021 Aug;20(8):2396-2408. doi: 10.1111/jocd.14258. Epub 2021 Jun 18.
Increased frequency of using alcohol-based hand sanitizers (ABHS) by consumers during COVID times have resulted in increased incidences of skin issues on palms.
(1) To quantify skin damage with increased usage frequency of ABHS by consumers and (2) To evaluate Virgin Coconut Oil (VCO) as natural prophylactic agent to counter the adverse effects.
In-home usage study was carried out with 60 volunteers for a 15-day intervention-Control Group: 6 applications per day of ABHS and Test Group: Overnight VCO use (6-8 drops) followed by 6× usage per day of ABHS. This leg included dermatological evaluation and WHO Self-Assessment Scale for skin health. Another leg of measurement included non-invasive instrumental study (Moisture & TEWL Probes, Tape Strip for protein content and IR spectroscopy for protein & lipid content) on forearm of 12 subjects (25-60 years age) with and without VCO application and repeated alcohol exposure.
In-home usage study established consumer experiencing skin protective effect of VCO in the context of ABHS onslaught. 25% increase in perceived moisture content was recorded for VCO users, using WHO Self-Assessment Scale. Instrumental studies confirmed an increase in TEWL and decrease in lipids & protein content. Overnight VCO application resists the extraction which builds up with repeated application.
Current work provides evidence of compromised hand skin barrier with ABHS daily usage. Overnight VCO application helps prepare the skin for next day alcohol use. Based on the findings, a regimen of overnight VCO application on hands as a natural prophylactic is recommended.
在 COVID 期间,消费者越来越频繁地使用含酒精的手部消毒剂(ABHS),导致手掌皮肤问题的发生率增加。
(1)量化消费者增加 ABHS 使用频率导致的皮肤损伤;(2)评估初榨椰子油(VCO)作为对抗不良反应的天然预防剂。
对 60 名志愿者进行了家庭使用研究,为期 15 天。对照组:每天使用 ABHS 6 次;试验组:每晚使用 VCO(6-8 滴),然后每天使用 ABHS 6 次。这部分包括皮肤学评估和世卫组织皮肤健康自我评估量表。另一部分测量包括非侵入性仪器研究(水分和 TEWL 探头、用于蛋白质含量的胶带条以及用于蛋白质和脂质含量的红外光谱),在有和没有 VCO 应用和重复酒精暴露的情况下,对 12 名 25-60 岁受试者的前臂进行测量。
家庭使用研究确立了 VCO 在 ABHS 冲击下对消费者皮肤的保护作用。使用世卫组织自我评估量表,VCO 用户记录到感知水分含量增加了 25%。仪器研究证实 TEWL 增加,脂质和蛋白质含量减少。夜间 VCO 应用可抵抗因重复应用而导致的提取。
目前的工作提供了证据表明,ABHS 的日常使用会损害手部皮肤屏障。夜间 VCO 应用有助于为第二天的酒精使用做好皮肤准备。基于这些发现,建议对手部进行夜间 VCO 应用作为天然预防剂的方案。