Gil Sáenz F J, Herranz Aguirre M, Durán Urdániz G, Zandueta Pascual L, Gimeno Ballester J, Bernaola Iturbe E
Servicio de Pediatría, Hospital García Orcoyen, Estella, 31200, Spain.
An Sist Sanit Navar. 2014 Sep-Dec;37(3):449-53. doi: 10.4321/s1137-66272014000300017.
Staphylococcal scalded skin syndrome (SSSS) is a dermatologic disease caused by exotoxins produced by Staphylococcus aureus. The disease presents as a painful cutaneous rash that culminates with the detachment of the superficial dermis. The usual treatment is antibiotics with beta-lactamase resistant penicillin. We report the case of a patient who presented with SSSS with initial torpid evolution despite antibiotic treatment and after the introduction of clindamycin IV experienced a very significant improvement. Concerns about the increase of methicillin resistant Staphylococcus aureus (MRSA) and the pathophysiology of this disease make bacteriostatic spectrum antistaphylococcal antibiotics, such as clindamycin, strong candidates for consideration as a first-line therapeutic arsenal for the treatment of SSSS.
葡萄球菌性烫伤样皮肤综合征（SSSS）是一种由金黄色葡萄球菌产生的外毒素引起的皮肤病。该疾病表现为疼痛性皮疹，最终导致浅表真皮脱落。通常的治疗方法是使用对β-内酰胺酶有抗性的青霉素类抗生素。我们报告了一例患有SSSS的患者，尽管进行了抗生素治疗，但病情最初进展缓慢，在静脉注射克林霉素后病情有了非常显著的改善。鉴于耐甲氧西林金黄色葡萄球菌（MRSA）的增加以及该疾病的病理生理学，具有抑菌谱的抗葡萄球菌抗生素，如克林霉素，成为治疗SSSS一线治疗药物的有力候选者。
